Results 231 to 240 of about 406,930 (327)

Ein neuer Malariawirkstoff hemmt die Proteinsynthese von Plasmodium falciparum

Angewandte Chemie, EarlyView.
Die Verbindung 31 stellt einen vielversprechenden Ansatz für die Entwicklung eines Malariawirkstoffs mit einem starken Wirkungsprofil dar (PfNF54 IC50 ± s.d. = 3,9 ± 0,4 nM). Sie hat einen neuartigen Wirkmechanismus, indem sie an zytosolische Ribosomen‐Untereinheiten bindet und dadurch die Proteinsynthese im Parasiten hemmt.
Patricia Bravo, Eleonora Diamanti, Mostafa M. Hamed, Lorenzo Bizzarri, Natalie Wiedemar, Armin Passecker, Nicolas M. B. Brancucci, Anna Albisetti, Christin Gumpp, Boris Illarionov, Markus Fischer, Matthias Witschel, Tobias Schehl, Hannes Hahne, Pascal Mäser, Matthias Rottmann, Anna K. H. Hirsch   +16 more
wiley   +1 more source

The stringent response does not influence ribosome pausing in Bacillus subtilis. [PDF]

Nucleic Acids Res
Han Y, Agnolin A, van der Kloet F, Sauer C, Costea PI, Felle MF, Appelbaum M, Hamoen LW.   +7 more
europepmc   +1 more source

Eine molekulare Maschine steuert die Synthese eines Rotaxans

Angewandte Chemie, EarlyView.
Eine lichtgetriebene molekulare Maschine wickelt einen flexiblen Strang um eine starre Achse und synthetisiert dabei ein Rotaxan. Dieser maschinengesteuerte Ansatz ermöglicht den Zugang zu molekularen Strukturen, die bislang durch Assemblierung oder Templatstrategien nicht zugänglich waren und demonstriert eine verallgemeinerbare Methode zur ...
Robert Kluifhooft, Tommy Wachsmuth, Bob Barthel, Mira Müller, Ann‐Kathrin Rückert, Michael Kathan   +5 more
wiley   +1 more source

Translational coupling of neighboring genes in prokaryotes. [PDF]

J Bacteriol
Brown KM, Wade JT.
europepmc   +1 more source

A Novel Antimalarial Agent that Inhibits Protein Synthesis in Plasmodium falciparum

Angewandte Chemie International Edition, EarlyView.
Compound 31 represents a promising avenue for the development as an antimalarial agent with a potent activity profile (PfNF54 IC50 ± s.d. = 3.9 ± 0.4 nM). It has a novel mode of action by binding to cytosolic ribosomal subunits, thereby inhibiting protein synthesis in the parasite.
Patricia Bravo, Eleonora Diamanti, Mostafa M. Hamed, Lorenzo Bizzarri, Natalie Wiedemar, Armin Passecker, Nicolas M. B. Brancucci, Anna Albisetti, Christin Gumpp, Boris Illarionov, Markus Fischer, Matthias Witschel, Tobias Schehl, Hannes Hahne, Pascal Mäser, Matthias Rottmann, Anna K. H. Hirsch   +16 more
wiley   +1 more source

How hard is it to encapsulate life? The general constraints on encapsulation. [PDF]

Philos Trans R Soc Lond B Biol Sci
Kempes CP, Avila D, Mathis C.
europepmc   +1 more source

Molecular basis of RNase I-mediated rRNA degradation regulated by ribosomes [PDF]

Atsushi Minami, Takehito Tanzawa, Zhuohao Yang, Takashi Funatsu, Tomohisa Kuzuyama, Hideji Yoshida, Takayuki Kato, Tetsuhiro Ogawa   +7 more
openalex   +1 more source

A Molecular Machine Directs the Synthesis of a Rotaxane

Angewandte Chemie International Edition, EarlyView.
A light‐driven molecular machine winds a flexible strand around a rigid axle to synthesize a rotaxane. This machine‐directed approach enables access to molecular shapes previously unattainable by assembly or templating, demonstrating a generalizable strategy for expanding the chemical space of mechanically bonded molecules.
Robert Kluifhooft, Tommy Wachsmuth, Bob Barthel, Mira Müller, Ann‐Kathrin Rückert, Michael Kathan   +5 more
wiley   +1 more source

Mechanistic insights into 50<i>S</i> precursor recognition and targeting by erythromycin resistance methyltransferase. [PDF]

Sci Adv
Sengupta S, Mukherjee R, Pilsl M, Bagale S, Adhikary AD, Borkar AN, Pradeepkumar PI, Engel C, Chowdhury A, Kaushal PS, Anand R.   +10 more
europepmc   +1 more source

A Tolerogenic Plasmid Inhibits Autoantibody Production Triggered by Immunization With Human Peptidyl Arginine Deiminase 4

Arthritis &Rheumatology, EarlyView.
Objective Rheumatoid arthritis (RA) is usually preceded and likely mediated by autoantibodies to citrullinated proteins (ACPAs) that recognize citrulline residues on multiple proteins. Conversion of arginine into citrulline is performed by enzymes called peptidyl arginine deiminases (PADs). We have previously demonstrated that the human PAD4 (hPAD4) is
Philippe P. Pagni, Vijetha Kumar, Nathalie C. Lambert, Eva Frison, Herve Luche, Marielle Mello, Magali Torres, Johnna D. Wesley, Matthias von Herrath, Jean Roudier, Isabelle Auger   +10 more
wiley   +1 more source