Results 231 to 240 of about 237,830 (385)

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

ChemBioChem, EarlyView.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout, Marie‐Christine Maurel   +1 more
wiley   +1 more source

Identification of regulatory variants of carboxylesterase 1 (CES1): A proof‐of‐concept study for the application of the Allele‐Specific Protein Expression (ASPE) assay in identifying cis‐acting regulatory genetic polymorphisms

PROTEOMICS, Volume 23, Issue 1, January 2023., 2023
Abstract It is challenging to study regulatory genetic variants as gene expression is affected by both genetic polymorphisms and non‐genetic regulators. The mRNA allele‐specific expression (ASE) assay has been increasingly used for the study of cis‐acting regulatory variants because cis‐acting variants affect gene expression in an allele‐specific ...
Lucy Her, Jian Shi, Xinwen Wang, Bing He, Logan S. Smith, Hui Jiang, Hao‐Jie Zhu   +6 more
wiley   +1 more source

Structural basis for hygromycin B inhibition of yeast pseudouridine-deficient ribosomes. [PDF]

Sci Adv
Zhao Y, Xu C, Chen X, Jin H, Li H.
europepmc   +1 more source

Ribosomes from Rat Liver Mitochondria

, 1967
Thomas W. O’Brien, George F. Kalf
openalex   +1 more source

Engineering and Structural Elucidation of a Sac7d‐Derived IgG Fc‐Specific Affitin and Its Application for the Light‐Controlled Affinity Purification of Antibodies

ChemBioChem, EarlyView.
An affitin derived from the Sac7d scaffold enables the light‐controlled affinity purification of antibodies under physiological conditions, thus overcoming limitations of protein A chromatography. X‐ray crystallographic analysis and affinity measurements reveal complex formation with Fc at the CH2/CH3 junction, similar to protein A/G and FnRn. Combined
Felix Veitl, Andreas Eichinger, Peter Mayrhofer, Markus R. Anneser, Mauricio Testanera, Kilian Rauscher, Matthias Lenz, Arne Skerra   +7 more
wiley   +1 more source

Nucleolar origins: challenging perspectives on evolution and function. [PDF]

Open Biol
Muñoz-Velasco I, Herrera-Escamilla AK, Vázquez-Salazar A.   +2 more
europepmc   +1 more source

The Synthesis of Ribosomes in E. coli

, 1962
Brian J. McCarthy, Roy J. Britten
openalex   +1 more source

The effect of pancreatic ribonuclease on rabbit reticulocyte ribosomes and its interpretation in terms of ribosome structure [PDF]

, 1969
Robert A. Cox
openalex   +1 more source

Nanosecond Hyperquenching for Electron Cryo‐Microscopy Without Air‐Water Interface Artifacts

Chemistry – A European Journal, EarlyView.
A novel method for the ultrafast vitrification of the biological assemblies is assayed by the electron cryotomography. Protein specimens prepared by this method inherently lack the spatial/structural artifacts, which derive from the surface tension at the air‐water interface (AWI).
Utz H. Ermel, Harald Schwalbe, Alexey V. Cherepanov   +2 more
wiley   +1 more source

Built differently or defective: can RNA exosomopathies cause ribosome heterogeneity? [PDF]

Philos Trans R Soc Lond B Biol Sci
Bressman ZJ, Corbett AH, Ghalei H.
europepmc   +1 more source