Results 271 to 280 of about 406,930 (327)

Toward a Genetic Signature of Resistance to Activity‐Based Anorexia in Striatal Projecting Cortical Neurons

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Converging evidence from neuroimaging studies and genome‐wide association study (GWAS) suggests the involvement of prefrontal cortex (PFC) and striatum dysfunction in the pathophysiology of anorexia nervosa (AN). However, identifying the causal role of circuit‐specific genes in the development of the AN‐like phenotype remains ...
K. Huang, M. A. Magateshvaren Saras, K. Conn, E. Greaves, F. Reed, S. Tyagi, H. Munguba, C. J. Foldi   +7 more
wiley   +1 more source

Cryo-EM structure of the naked mole-rat ribosome reveals a stabilized split 28S rRNA

Gül M, Rossi A, Spahn CM, Lewin GR, Kudryashev M.   +4 more
europepmc   +1 more source

Cycloheximide resistant ribosomes reveal adaptive translation dynamics in C. elegans. [PDF]

Genetics
Zhao Q, Bolton B, Rothe R, Tachibana R, Cenik C, Sarinay Cenik E.   +5 more
europepmc   +1 more source

Structural Basis of T Cell Toxicity Induced by Tigecycline Binding to the Mitochondrial Ribosome

Joanna Rorbach, Qiuya Shao, Anas Khawaja, Minh Nhat Nguyen, Vivek Singh, Jingdian Zhang, Monica Adori, C.A. Innis, Xaquín Castro Dopico   +8 more
openalex   +1 more source

Creativity and its link to epilepsy

Epilepsia Open, EarlyView.
Abstract Creative thinking represents one of our highest‐order cognitive processes, involving multiple cortical structures and an intricate interplay between several cortical and subcortical networks. It results in novel ideas that translate to useful products or concepts. The evolutionary purpose of creativity is therefore apparent, as it advances our
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain

, 2017
Nathanael G. Lintner, Kim F. McClure, Donna N. Petersen, Allyn T. Londregan, David W. Piotrowski, Liuqing Wei, Jun Xiao, Michael W. Bolt, Paula M. Loria, Bruce A. Maguire, Kieran F. Geoghegan, Austin Huang, Tim Rolph, Spiros Liras, Jennifer A. Doudna, Robert Dullea, J.H.D. Cate   +16 more
openalex   +2 more sources

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Translation stalling in neurons: a critical mechanism for timely protein delivery to distal cellular processes. [PDF]

Biochem Soc Trans
Sun J, Drever L, Ortega J, Sossin WS.
europepmc   +1 more source

Ribosome-associated protein quality control

Nature Structural &Molecular Biology, 2016
Onn Brandman, R. Hegde
semanticscholar   +1 more source

Extracellular Vesicle‐Based mRNA Therapeutics and Vaccines

Exploration, EarlyView.
This review provides a comprehensive analysis of recent advancements in extracellular vesicle (EV)‐based messenger RNA (mRNA) applications for therapeutics and vaccines. It systematically outlines strategies for mRNA encapsulation within EVs and elucidates the challenges associated with this technology, offering insights into future research directions
Qi Li, Haonan Xing, Abid Naeem, Kaiyue Zhang, Aiping Zheng, Yuanyu Huang, Mei Lu   +6 more
wiley   +1 more source