Results 291 to 300 of about 406,930 (327)

Selective silencing of antibiotic-tethered ribosomes as a resistance mechanism against aminoglycosides. [PDF]

Nat Commun
Ghosh Dastidar N, Freyer NS, Petrychenko V, de A P Schwarzer AC, Peng BZ, Samatova E, Kothe C, Schmidt M, Peske F, Politi AZ, Urlaub H, Fischer N, Rodnina MV, Wohlgemuth I.   +13 more
europepmc   +1 more source

Advances in Detecting RNA Modifications Using Direct RNA Nanopore Sequencing

Advanced Genetics, EarlyView.
This review examines recent advances in Oxford Nanopore Technologies direct RNA sequencing, highlighting its expanding capacity to detect RNA modifications beyond m6A. It discusses computational frameworks and basecalling innovations that enable single‐nucleotide and single‐molecule resolution, explores co‐occurring modifications and their regulatory ...
Yaran Liu, Yang Li, Qiang Sun
wiley   +1 more source

NAC couples protein synthesis with nascent polypeptide myristoylation on the ribosome. [PDF]

EMBO J
Zdancewicz S, Maldosevic E, Malezyna K, Jomaa A.   +3 more
europepmc   +1 more source

hiPSC‐Derived Astrocytes From Individuals With Schizophrenia Induce a Dystrophic Phenotype in Microglial‐Like Cells

Glia, EarlyView.
SCZ astrocytes display an increased pro‐inflammatory profile upon TNF‐α stimulation. Reactive SCZ astrocytes induce microglial‐like cells to assume a dystrophic phenotype. Reactive SCZ astrocytes limit iMGs' synaptoneurosome uptake and migration. ABSTRACT Neuroinflammation, particularly astrocyte reactivity, is increasingly linked to schizophrenia (SCZ)
Pablo L. Cardozo, Chia‐Yi Lee, Juliana P. S. Lacerda, Júlia S. Fahel, Pablo Trindade, Gabriela Vitória, Leonardo Chicaybam, Rafaela C. Cordeiro, Isaque J. S. de Faria, Nathália C. Silva, Yaovi M. H. Todjro, Joana C. do P. Maciel, Martin H. Bonamino, Luciene B. Vieira, Breno F. Cruz, Rodrigo Nicolato, Kristen J. Brennand, Stevens K. Rehen, Fabíola M. Ribeiro   +18 more
wiley   +1 more source

SERBP1: A Multifunctional RNA-Binding Protein Linking Gene Expression, Cellular Metabolism, and Diseases. [PDF]

Cells
Ji Z, Ablimit A.
europepmc   +1 more source

Application of Artificial Intelligence in Clinical Microbiology: From Research to Practice

iLABMED, EarlyView.
This paper reviews the application of AI in clinical microbiology practice at home and abroad, including rapid pathogen identification, accurate characterization of microbial resistance patterns, optimization of laboratory workflows, and public health interventions.
Ting Ding, Yi‐Wei Tang, Xiaoke Hao
wiley   +1 more source

Human protein synthesis requires aminoacyl-tRNA pivoting during proofreading. [PDF]

Nat Commun
Sapkota D, Sanbonmatsu KY, Girodat D.
europepmc   +1 more source

An Interpretable Machine Learning Model for Predicting 5‐Year Survival in Breast Cancer Based on Integration of Proteomics and Clinical Data

iMetaMed, EarlyView.
This study first introduced Kolmogorov–Arnold Network (KAN) into the deep learning model for the integration of clinical and proteomics data in predicting 5‐year survival in breast cancer. The optimal predictive model with 13 key predictors demonstrated excellent predictive performance with strong accuracy, precision, and F1.
Zhixuan Wu, Shengnan Yao, Lingli Jin, Xue Wu, Rongrong Zhang, Ouchen Wang, Erjie Xia   +6 more
wiley   +1 more source

Wuda Granule Improves the Gastrointestinal Motility via Gut‐Brain Axis in Beagle Dogs

iMetaMed, EarlyView.
Stress sensors were implanted in the gastric body, sinus, duodenum, jejunum, and colon of beagle dogs to record gastrointestinal motility. Gastrointestinal contractile motility was assessed before and after the lateral ventricular injection of Wuda granule, intravenous atropine instillation, and bilateral cervical vagotomy.
Zhi Jiang, Xing Li, Qicheng Chen, Zhiqiang Chen, Lixing Cao, Hailin Tang   +5 more
wiley   +1 more source

Editor's Note on 'The human insulin receptor mRNA contains a functional internal ribosome entry segment'. [PDF]

Nucleic Acids Res
europepmc   +1 more source