Results 121 to 130 of about 173,360 (283)

DEAD-box RNA helicase 10 is required for 18S rRNA maturation by controlling the release of U3 snoRNA from pre-rRNA in embryonic stem cells

Nature Communications
Ribosome biogenesis plays a pivotal role in maintaining stem cell homeostasis, yet the precise regulatory mechanisms governing this process in mouse embryonic stem cells (mESCs) remain largely unknown.
Xiuqin Wang, Gongcheng Hu, Lisha Wang, Yuli Lu, Yanjiang Liu, Shengxiong Yang, Junzhi Liao, Qian Zhao, Qiuling Huang, Wentao Wang, Wenjing Guo, Heying Li, Yu Fu, Yawei Song, Qingqing Cai, Xiaofei Zhang, Xiangting Wang, Yue-Qin Chen, Xiaorong Zhang, Hongjie Yao   +19 more
doaj   +1 more source

Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness

eLife, 2019
To achieve maximal growth, cells must manage a massive economy of ribosomal proteins (r-proteins) and RNAs (rRNAs) to produce thousands of ribosomes every minute.
Blake W Tye, Nicoletta Commins, Lillia V. Ryazanova, M. Wühr, Michael Springer, David Pincus, David Pincus, L. S. Churchman   +7 more
semanticscholar   +1 more source

An Interpretable Machine Learning Model for Predicting 5‐Year Survival in Breast Cancer Based on Integration of Proteomics and Clinical Data

iMetaMed, EarlyView.
This study first introduced Kolmogorov–Arnold Network (KAN) into the deep learning model for the integration of clinical and proteomics data in predicting 5‐year survival in breast cancer. The optimal predictive model with 13 key predictors demonstrated excellent predictive performance with strong accuracy, precision, and F1.
Zhixuan Wu, Shengnan Yao, Lingli Jin, Xue Wu, Rongrong Zhang, Ouchen Wang, Erjie Xia   +6 more
wiley   +1 more source

Proteogenomic Analysis Identifies Clinically Relevant Subgroups of Collecting Duct Carcinoma

Research
Collecting duct carcinoma (CDC) is a rare but aggressive form of renal cell carcinoma (RCC) that has limited understanding and an undefined systemic therapeutic regimen. Herein, we conducted a comprehensive proteogenomic analysis of CDC tumors and normal
Yuanyuan Qu, Xiaoru Pei, Jinwen Feng, Xin Yan, Linhui Zhang, Jun Wang, Xin Yao, Jiasheng Bian, Yu Gan, Hualei Gan, Xuewen Jiang, Ping Yang, Maoping Cai, Liqing Li, Xinqiang Wu, Weiwei Jing, Chao Zhang, Jianyuan Zhao, Hailiang Zhang, Guohai Shi, Xiang Zhou, Dingwei Ye, Chen Ding   +22 more
doaj   +1 more source

Homoharringtonine suppresses acute myeloid leukemia progression by orchestrating EWSR1 phase separation in an m6A‐YTHDF2‐dependent mechanism

iMeta, EarlyView.
Homoharringtonine (HHT), a clinically approved anti‐leukemic drug, directly binds the RNA‐binding protein EWSR1. HHT induces an allosteric conformational switch in the RNA recognition motif of EWSR1, driving self‐association and liquid–liquid phase separation (LLPS). The resulting condensates act as regulatory hubs that sequester the m6A reader YTHDF2,
Ting‐Ting Liu, Li‐Ting Chen, Xu‐Ying Pei, Shao‐Nan Hu, Fang‐Fang Zhuo, Ze‐Kun Chen, Yang Liu, Jing‐Kang Wang, Ji‐Chao Zhang, Qi Cao, Ling Li, Jing Wang, Tian‐Tian Wei, Bo Han, Peng‐Fei Tu, Xiang‐Yu Zhao, Ruidong Xue, Ke‐Wu Zeng   +17 more
wiley   +1 more source

Single‐nucleus RNA sequencing reveals RUNX1 regulation of muscle hypertrophy through PI3K/AKT/mTOR pathway

iMeta, EarlyView.
We used snRNA‐seq to construct a high‐resolution atlas of pectoral muscle development in broiler chickens from neonatal to adult stages. This analysis revealed pronounced molecular heterogeneity among satellite cells across developmental phases and uncovered a previously uncharacterized Runx1+ satellite cell subpopulation.
Chenxu Wang, Junjie Ma, Yibin Wang, Rui Liu, Chenxi Zhang, Qingyuan Li, Lixin Zhang, Qihang Hou, Xiaojun Yang   +8 more
wiley   +1 more source

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Placeholder factors in ribosome biogenesis: please, pave my way [PDF]

, 2017
Francisco J. Espinar‐Marchena, Reyes Babiano, Jesús de la Cruz   +2 more
openalex   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Ribosome biogenesis controls cranial suture MSC fate via the complement pathway in mouse and human iPSC models

, 2023
Supawadee Jariyasakulroj, Wei Zhang, Jianhui Bai, Minjie Zhang, Zhipeng Lu, Jian-Fu Chen   +5 more
openalex   +1 more source