Results 91 to 100 of about 78,302 (265)
British Journal of Haematology, EarlyView.Summary Over the past decade, there has been a substantial increase in the diversity and number of therapeutic options for myeloproliferative neoplasms (MPNs). While many remain within the clinical trial arena, the clinician and patient community have seen more approvals reaching the clinic and a rethink on how best we should be approaching these ...
Trung Q. Ngo +3 more
wiley +1 more source
British Journal of Haematology, EarlyView.Summary Patients with relapsed or refractory acute myeloid leukaemia (r/r AML) harbouring FMS‐like tyrosine kinase 3 (FLT3) mutations generally have poor prognosis and limited treatment options. The second‐generation FLT3 inhibitor gilteritinib provides better disease control compared to standard relapse therapies and was approved based on two ...
Desiree Kunadt +55 more
wiley +1 more source
Distinct clinical and genetic characteristics of myelodysplastic syndrome in younger patients
British Journal of Haematology, EarlyView.Summary Myelodysplastic neoplasms (formerly myelodysplastic syndromes, MDS) are heterogeneous clonal haematological malignancies that primarily affect the elderly, though a notable proportion of patients are diagnosed at younger ages. We retrospectively analysed 1437 patients diagnosed or treated at Asan Medical Center between 1989 and 2022, comparing ...
Hyunkyung Park +15 more
wiley +1 more source
Фармакокинетика и Фармакодинамика, 2017 Group B vitamins are characterized by neuroprotective effects. Mechanisms of action of synergistic combinations of various vitamins are insufficiently studied.
O. A. Gromov +2 more
doaj
Impact of rapid investigation clinic on timeliness of lung cancer diagnosis and treatment
BMC Pulmonary Medicine, 2017 Background Guidelines recommend timely evaluation of patients with suspected lung cancer. We evaluated the impact of a Rapid Investigation Clinic (RIC) on timeliness of lung cancer diagnosis and treatment between February 2010 and December 2011.
Nicole Ezer +4 more
doaj +1 more source
British Journal of Haematology, EarlyView.After adjusting for confounders, the ibrutinib cohort had significantly better overall survival (adjusted hazard ratio, 0.39; 95% confidence interval, 0.23–0.68; p = 0.0008) than the allogeneic haematopoietic stem cell transplantation (alloHSCT) cohort.
Farrukh T. Awan +8 more
wiley +1 more source
British Journal of Haematology, EarlyView.Summary Unrelated cord blood transplantation (CBT) is an important alternative donor option for adult patients with myelodysplastic syndrome (MDS); however, the prognostic significance of cord blood unit characteristics following CBT remains unclear and may vary according to disease risk.
Takaaki Konuma +23 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose G protein‐coupled receptors (GPCRs) are major drug targets, yet many orphan receptors remain poorly characterized. GPR139 has been implicated in CNS disorders, including schizophrenia and depression, but its signalling mechanisms remain unclear.
Boris Trapkov +2 more
wiley +1 more source
Protected areas on international borders show uneven conservation outcomes
Conservation Biology, EarlyView.Abstract Border protected areas (BPAs) are national protected areas that are immediately adjacent to a country's border or span two or more countries; they are characterized by distinctive opportunities and pressures. They play a critical role in protecting carbon‐rich ecosystems, conserving endangered biodiversity, reducing cross‐border environmental ...
Rachakonda Sreekar +10 more
wiley +1 more source
Sleep profiles in individuals with rare neurogenetic syndromes
Developmental Medicine &Child Neurology, EarlyView.Aim To characterize sleep profiles in individuals with neurogenetic disorders (NGDs) and examine the contribution of key clinical and psychiatric symptoms to these profiles. Method The parents of 248 individuals (aged 3–45 years) diagnosed with a range of NGDs, including PTEN hamartoma tumor syndrome (n = 111), SYNGAP1‐related intellectual disability ...
Isabella C. Reyes +7 more
wiley +1 more source