Results 61 to 70 of about 588,381 (221)

The amino terminal domain of the human α7 nicotinic acetylcholine receptor subunit leads to the functional expression of human/insect receptors

British Journal of Pharmacology, EarlyView.
Human α7 receptors have been characterised in terms of pharmacological properties. Insertion of the N‐terminal domain of the human α7 subunit leads to honeybee and cockroach chimeric receptors activated by ACh and inhibited by α‐Bgt. Insertion of the human cys‐loop leads to cockroach chimeric receptors modulated by PNU.
Alison Cartereau, Chloé Veront, Alexandra Cremades, Priscilla Martin, Remi Gojard, Nicolas Galland, Emiliane Taillebois, Dieudonnée Togbé, Jean‐Yves Le Questel, Steeve H. Thany   +9 more
wiley   +1 more source

The Effects of Nutrient Additions on Kokanee in Dworshak Reservoir, Idaho

Fisheries Management and Ecology, EarlyView.
ABSTRACT We investigated the effects of whole reservoir nitrogen (N) addition on kokanee growth in Dworshak Reservoir, Idaho. We hypothesized that N addition would improve the growth of kokanee (Oncorhynchus nerka) at a given level of abundance by increasing the availability of Daphnia, an important food source.
Sean M. Wilson, Matthew P. Corsi, Eric J. Stark, Eli A. Felts, Andrew M. Dux, Ryan S. Hardy   +5 more
wiley   +1 more source

Systematic analysis of Fc mutations designed to reduce binding to Fc-gamma receptors

mAbs
Elimination of the binding of immunoglobulin Fc to Fc gamma receptors is highly desirable for the avoidance of unwanted inflammatory responses to therapeutic antibodies and fusion proteins. Many different approaches have been used in the clinic, but they
Geoff Hale, Jelle De Vos, Alastair Douglas Davy, Koen Sandra, Ian Wilkinson   +4 more
doaj   +1 more source

Integration of Fiber-Optic Sensor Arrays into a Multi-Modal Tactile Sensor Processing System for Robotic End-Effectors

Sensors, 2014
With the increasing complexity of robotic missions and the development towards long-term autonomous systems, the need for multi-modal sensing of the environment increases.
Peter Kampmann, Frank Kirchner
doaj   +1 more source

Plasma obtained following murine hindlimb ischemic conditioning protects against oxidative stress in zebrafish models through activation of nrf2a and downregulation of duox.

PLoS ONE, 2021
Ischemia/reperfusion of organ systems in trauma patients with resuscitated hemorrhagic shock (HSR) contributes to tissue injury and organ dysfunction.
Rui Guan, Xiao-Yan Wen, Chung Ho Leung, Caterina Di Ciano-Oliveira, Stephen Lam, Si Yuan Dai, Farhad Karbassi, Antonio Mauro, Youdong Wang, Ori Rotstein   +9 more
doaj   +1 more source

Benefit of immune checkpoint inhibitors as adjuvant treatment for acral melanomas

Journal of the European Academy of Dermatology and Venereology, EarlyView.
When questioning the effectiveness of adjuvant immunotherapy for acral melanomas, we found no clinical benefit to the adjuvant proposal, despite the maintenance of adverse effects. Abstract Background Solar factors play no role in the development of acral melanoma (AM). AM is characterized by low cumulative solar damage (low CSD).
Damien Sanogo, Romain Levard, Julie Cassecuel, Amir Khammari, Gaelle Quereux, Florent Grange, Henri Montaudié, Florence Brunet‐Possenti, Justine Lavaud, Marie‐Thérèse Leccia, Géraldine Jeudy, Anne Dompmartin, Brigitte Dreno, Jean‐Matthieu L’Orphelin   +13 more
wiley   +1 more source

Somebody Knows Something: Managerial Ability, Product Development, and Return‐on‐Investment in a Hit‐Driven Industry

Journal of Economics &Management Strategy, EarlyView.
ABSTRACT In hit‐driven industries, product development is associated with a right‐skewed unconditional distribution of performance, and products in the right tail have outsized impacts. Understanding how exceptional performance is generated can improve resource allocation, but the literature advances two different narratives: one emphasizes postrelease
Darren Filson
wiley   +1 more source

Influence and convergence to higher standards: The dual examination of pharmaceutical patents in Brazil

The Journal of World Intellectual Property, EarlyView.
Abstract Between 2001 and 2021, pharmaceutical patent applications filed in Brazil were examined by the patent office (INPI) and the national health regulator (Anvisa). This paper investigates how health regulators can contribute to patent examination by shifting the set of criteria cited as grounds for 2589 negative decisions from both entities ...
Eduardo Mercadante
wiley   +1 more source

Turbulence energetics in stably stratified geophysical flows: strong and weak mixing regimes

, 2008
Traditionally, turbulence energetics is characterized by turbulent kinetic energy (TKE) and modelled using solely the TKE budget equation. In stable stratification, TKE is generated by the velocity shear and expended through viscous dissipation and work ...
Abarbanel, Abarbanel, Bange, Canuto, Canuto, Canuto, Chandrasekhar, Cheng, Churchill, Dalaudier, Elperin, Esau, Galperin, Hanazaki, Hanazaki, Hansen, Holloway, Hunt, Jin, Kaimal, Keller, Kim, Kolmogorov, Lawrence, Lilly, Lorenz, Lorenz, Luyten, Mahrt, Mauritsen, Mauritsen, Miles, Miles, Monin, Monin, Monti, Nappo, Ohya, Phillips, Phillips, Polyakov, Poulos, Prandtl, Rehmann, Rehmann, Richardson, Schumann, Smedman, Strang, Taylor, Tennekes, Turner, Umlauf, Uttal, Zilitinkevich, Zilitinkevich   +55 more
core   +1 more source

The Role of Labour Market Institutions in Shaping Euro Area Monetary Policy Transmission

Oxford Bulletin of Economics and Statistics, EarlyView.
ABSTRACT We examine how labour market institutions shape monetary policy transmission in euro area countries. A theoretical model suggests that higher union density flattens the Phillips curve, amplifying output responses while dampening the inflation effects of monetary shocks. This is empirically confirmed using an interacted panel VAR.
Maximilian Boeck, Christian Glocker
wiley   +1 more source