Results 1 to 10 of about 49,432 (164)
LGR signaling and metabolic regulation: A new frontier in addressing insulin resistance and diabetes treatment. [PDF]
J Diabetes InvestigLGR signaling plays a crucial role in metabolic regulation by coordinating muscle‐neuron‐adipose tissue crosstalk. In response to a high‐sugar diet, muscle‐derived BMP signaling activates neuronal Bursicon, which stimulates insulin secretion and enhances adipose insulin sensitivity.
Aoyama T, Yamauchi T.
europepmc +2 more sources
Clinical periodontal diagnosis
Periodontology 2000, EarlyView., 2023 Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi +5 more
wiley +1 more source
Nature, 1947 IN his address to the Seventh Congress of Biological Chemistry in Liege on October 3–6, 1946, Dr. H. D. Kay summarized some experiments on feeding pigs with yeast, carried out during the War at the National Institute for Research in Dairying in Reading1.
T J, DE MAN, E, HOFF-JØRGENSEN
openaire +4 more sources
Ideology and disease identity : the politics of rickets, 1929-1982 [PDF]
, 2013 How can we assess the reciprocal impacts of politics and medicine in the contemporary period? Using the example of rickets in twentieth century Britain, I will explore the ways in which a preventable, curable non-infectious disease came to have enormous ...
Apple +50 more
core +1 more source
Burosumab therapy in children with x-linked hypophosphatemia [PDF]
, 2018 BACKGROUND X-linked hypophosphatemia is characterized by increased secretion of fibroblast growth factor 23 (FGF-23), which leads to hypophosphatemia and consequently rickets, osteomalacia, and skeletal deformities.
Boot, Annemieke M +13 more
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Canadian Medical Association Journal, 2006 What's your call? When enlargement of this boy's costochondral junctions was noted incidentally on a chest radiograph, additional skeletal images were ordered. They revealed widening, fraying, cupping and irregularity of the metaphyseal border of his distal radius and ulna (Fig. 1), with osteomalacia of his long bones. Fig.
Monique Robert +2 more
openaire +3 more sources
A novel pathogenic mutation of the CYP27B1 gene in a patient with vitamin D-dependent rickets type 1: a case report [PDF]
, 2014 BACKGROUND: Rickets can occur due to Vitamin D deficiency or defects in its metabolism. Three rare genetic types of rickets with different alterations of genes have been reported, including: Vitamin D dependent rickets type 1, Vitamin D dependent rickets
Abdulrahman MH Al Nemri +7 more
core +1 more source
Prevention of the disrupted enamel phenotype in Slc4a4-null mice using explant organ culture maintained in a living host kidney capsule. [PDF]
, 2014 Slc4a4-null mice are a model of proximal renal tubular acidosis (pRTA). Slc4a4 encodes the electrogenic sodium base transporter NBCe1 that is involved in transcellular base transport and pH regulation during amelogenesis.
Kurtz, Ira, Paine, Michael L, Wen, Xin
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Validation of a novel scoring system for changes in skeletal manifestations of hypophosphatasia in newborns, infants, and children: The Radiographic Global Impression of Change scale [PDF]
, 2018 Hypophosphatasia (HPP) is the heritable metabolic disease characterized by impaired skeletal mineralization due to low activity of the tissue-nonspecific isoenzyme of alkaline phosphatase.
Fujita, Kenji P +4 more
core +2 more sources