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The Lancet, 2014
Rickets, historically referred to as "the English disease", is common worldwide. Absence of phosphate at the growth plate and mineralising bone surfaces due to inadequate vitamin D supply either from sunlight exposure or diet is the main cause. Inherited disorders causing hypophosphataemia have shown the intricacies of phosphate metabolism.
Charlotte Jane, Elder +1 more
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Rickets, historically referred to as "the English disease", is common worldwide. Absence of phosphate at the growth plate and mineralising bone surfaces due to inadequate vitamin D supply either from sunlight exposure or diet is the main cause. Inherited disorders causing hypophosphataemia have shown the intricacies of phosphate metabolism.
Charlotte Jane, Elder +1 more
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Nature Reviews Disease Primers, 2017
Rickets is a bone disease associated with abnormal serum calcium and phosphate levels. The clinical presentation is heterogeneous and depends on the age of onset and pathogenesis but includes bowing deformities of the legs, short stature and widening of joints. The disorder can be caused by nutritional deficiencies or genetic defects.
Thomas O, Carpenter +5 more
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Rickets is a bone disease associated with abnormal serum calcium and phosphate levels. The clinical presentation is heterogeneous and depends on the age of onset and pathogenesis but includes bowing deformities of the legs, short stature and widening of joints. The disorder can be caused by nutritional deficiencies or genetic defects.
Thomas O, Carpenter +5 more
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Hormone Research in Paediatrics, 2000
X-Linked hypophosphataemic rickets (XLH) is frequently associated with short stature even when conventional treatment (1,25-dihydroxyvitamin D<sub>3</sub> or 1α-hydroxyvitamin D<sub>3</sub> plus inorganic phosphate salts) is administered for a long time. The pathogenesis of growth retardation is probably multifactorial. Affected
SAGGESE, GIUSEPPE, BARONCELLI GI
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X-Linked hypophosphataemic rickets (XLH) is frequently associated with short stature even when conventional treatment (1,25-dihydroxyvitamin D<sub>3</sub> or 1α-hydroxyvitamin D<sub>3</sub> plus inorganic phosphate salts) is administered for a long time. The pathogenesis of growth retardation is probably multifactorial. Affected
SAGGESE, GIUSEPPE, BARONCELLI GI
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Orthopaedic Nursing, 2004
Nutritional (vitamin D deficiency) rickets is now a rarity in the industrial world because of food fortification. Most cases result from hereditary inborn errors of vitamin D metabolism or end-organ unresponsiveness as is exemplified in this case of hypophosphatemic rickets.
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Nutritional (vitamin D deficiency) rickets is now a rarity in the industrial world because of food fortification. Most cases result from hereditary inborn errors of vitamin D metabolism or end-organ unresponsiveness as is exemplified in this case of hypophosphatemic rickets.
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The Journal of Pediatrics, 1975
Since the introduction of irradiated ergosterol into our food supply, nutritional vitamin D-deficiency rickets has become an uncommon disease. However, skeletal disorders due to abnormalities of vitamin D function still occur. These disorders can now be classified more exactly into two groups: those in which there is a deficiency of the active ...
Helen C. Harrison, Harold E. Harrison
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Since the introduction of irradiated ergosterol into our food supply, nutritional vitamin D-deficiency rickets has become an uncommon disease. However, skeletal disorders due to abnormalities of vitamin D function still occur. These disorders can now be classified more exactly into two groups: those in which there is a deficiency of the active ...
Helen C. Harrison, Harold E. Harrison
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Clinical Radiology, 1984
The radiological diagnosis of rickets is mainly based on the widened appearance of actively developing epiphyseal growth plates. In the adolescent with rickets the secondary iliac and ischial ossification centres may be abnormally wide when most other epiphyses have fused.
M. Chapman +3 more
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The radiological diagnosis of rickets is mainly based on the widened appearance of actively developing epiphyseal growth plates. In the adolescent with rickets the secondary iliac and ischial ossification centres may be abnormally wide when most other epiphyses have fused.
M. Chapman +3 more
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Pediatrics, 1957
Sixty-nine premature infants receiving different dietaries and with birth weights below 2,000 gm were studied with chemical, clinical and radiologic methods. Vitamin D was given to all infants from the age of 4 days. The concentrations of calcium, phosphorus and phosphatase in the serum showed variations toward those seen in active ...
S. Eek, L. H. Gabrielsen, S. Halvorsen
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Sixty-nine premature infants receiving different dietaries and with birth weights below 2,000 gm were studied with chemical, clinical and radiologic methods. Vitamin D was given to all infants from the age of 4 days. The concentrations of calcium, phosphorus and phosphatase in the serum showed variations toward those seen in active ...
S. Eek, L. H. Gabrielsen, S. Halvorsen
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Danish medical journal, 2008
Rickets is a heterogeneous group of diseases of the growing child caused by defect mineralization of bone. Nutritional rickets is caused by deficiency of vitamin D, calcium or both. Several hereditary forms of rickets exist where the disease proceeds into adulthood.
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Rickets is a heterogeneous group of diseases of the growing child caused by defect mineralization of bone. Nutritional rickets is caused by deficiency of vitamin D, calcium or both. Several hereditary forms of rickets exist where the disease proceeds into adulthood.
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Seminars in Musculoskeletal Radiology, 2002
Bone accretion is a two-stage process, with the osteoblasts laying down osteoid, which is then mineralized. Mineralization of osteoid requires vitamin D to be available in its active form (1,25(OH) 2 D); in addition, mineralization also requires normal levels of serum calcium, phosphorus, and alkaline phosphate. Deficiencies of any of these will result
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Bone accretion is a two-stage process, with the osteoblasts laying down osteoid, which is then mineralized. Mineralization of osteoid requires vitamin D to be available in its active form (1,25(OH) 2 D); in addition, mineralization also requires normal levels of serum calcium, phosphorus, and alkaline phosphate. Deficiencies of any of these will result
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Postgraduate Medicine, 1965
A brief survey of rickets is presented. Specific biochemical determinations establish whether rachitic changes are primary or secondary to systemic disease. If no underlying disease is present, the most likely diagnosis is vitamin D-refractory rickets. The difficulties in management of this form of the disease are emphasized.
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A brief survey of rickets is presented. Specific biochemical determinations establish whether rachitic changes are primary or secondary to systemic disease. If no underlying disease is present, the most likely diagnosis is vitamin D-refractory rickets. The difficulties in management of this form of the disease are emphasized.
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