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Nature Reviews Disease Primers, 2017
Rickets is a bone disease associated with abnormal serum calcium and phosphate levels. The clinical presentation is heterogeneous and depends on the age of onset and pathogenesis but includes bowing deformities of the legs, short stature and widening of joints. The disorder can be caused by nutritional deficiencies or genetic defects.
Thomas O, Carpenter +5 more
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Rickets is a bone disease associated with abnormal serum calcium and phosphate levels. The clinical presentation is heterogeneous and depends on the age of onset and pathogenesis but includes bowing deformities of the legs, short stature and widening of joints. The disorder can be caused by nutritional deficiencies or genetic defects.
Thomas O, Carpenter +5 more
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Hormone Research in Paediatrics, 2000
X-Linked hypophosphataemic rickets (XLH) is frequently associated with short stature even when conventional treatment (1,25-dihydroxyvitamin D<sub>3</sub> or 1α-hydroxyvitamin D<sub>3</sub> plus inorganic phosphate salts) is administered for a long time. The pathogenesis of growth retardation is probably multifactorial. Affected
SAGGESE, GIUSEPPE, BARONCELLI GI
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X-Linked hypophosphataemic rickets (XLH) is frequently associated with short stature even when conventional treatment (1,25-dihydroxyvitamin D<sub>3</sub> or 1α-hydroxyvitamin D<sub>3</sub> plus inorganic phosphate salts) is administered for a long time. The pathogenesis of growth retardation is probably multifactorial. Affected
SAGGESE, GIUSEPPE, BARONCELLI GI
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Orthopaedic Nursing, 2004
Nutritional (vitamin D deficiency) rickets is now a rarity in the industrial world because of food fortification. Most cases result from hereditary inborn errors of vitamin D metabolism or end-organ unresponsiveness as is exemplified in this case of hypophosphatemic rickets.
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Nutritional (vitamin D deficiency) rickets is now a rarity in the industrial world because of food fortification. Most cases result from hereditary inborn errors of vitamin D metabolism or end-organ unresponsiveness as is exemplified in this case of hypophosphatemic rickets.
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Seminars in Musculoskeletal Radiology, 2002
Bone accretion is a two-stage process, with the osteoblasts laying down osteoid, which is then mineralized. Mineralization of osteoid requires vitamin D to be available in its active form (1,25(OH) 2 D); in addition, mineralization also requires normal levels of serum calcium, phosphorus, and alkaline phosphate. Deficiencies of any of these will result
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Bone accretion is a two-stage process, with the osteoblasts laying down osteoid, which is then mineralized. Mineralization of osteoid requires vitamin D to be available in its active form (1,25(OH) 2 D); in addition, mineralization also requires normal levels of serum calcium, phosphorus, and alkaline phosphate. Deficiencies of any of these will result
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Wiener Medizinische Wochenschrift, 2004
Although rickets and osteomalacia posed a serious health problem in industrialised countries a hundred years ago, these diseases are now rarely found, and when, usually in certain risk groups. In underdeveloped countries, rickets is still a major public health problem due to inadequate calcium intake by children.
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Although rickets and osteomalacia posed a serious health problem in industrialised countries a hundred years ago, these diseases are now rarely found, and when, usually in certain risk groups. In underdeveloped countries, rickets is still a major public health problem due to inadequate calcium intake by children.
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Pediatric Clinics of North America, 2019
Hypophosphatemic rickets, mostly of the X-linked dominant form caused by pathogenic variants of the PHEX gene, poses therapeutic challenges with consequences for growth and bone development and portends a high risk of fractions and poor bone healing, dental problems and nephrolithiasis/nephrocalcinosis.
Martin, Bitzan, Paul R, Goodyer
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Hypophosphatemic rickets, mostly of the X-linked dominant form caused by pathogenic variants of the PHEX gene, poses therapeutic challenges with consequences for growth and bone development and portends a high risk of fractions and poor bone healing, dental problems and nephrolithiasis/nephrocalcinosis.
Martin, Bitzan, Paul R, Goodyer
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Journal of Pediatric Orthopaedics, 1982
Rickets secondary to hepatobiliary disease is a rare condition; however, the skeletal manifestations are similar to simple nutritional rickets. These skeletal changes include epiphyseal plate abnormalities, pseudofractures, bowing of long bones, scoliosis, and fractures.
M E, Holda, J R, Ryan
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Rickets secondary to hepatobiliary disease is a rare condition; however, the skeletal manifestations are similar to simple nutritional rickets. These skeletal changes include epiphyseal plate abnormalities, pseudofractures, bowing of long bones, scoliosis, and fractures.
M E, Holda, J R, Ryan
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Pediatrics, 1957
Sixty-nine premature infants receiving different dietaries and with birth weights below 2,000 gm were studied with chemical, clinical and radiologic methods. Vitamin D was given to all infants from the age of 4 days. The concentrations of calcium, phosphorus and phosphatase in the serum showed variations toward those seen in active ...
S, EEK, L H, GABRIELSEN, S, HALVORSEN
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Sixty-nine premature infants receiving different dietaries and with birth weights below 2,000 gm were studied with chemical, clinical and radiologic methods. Vitamin D was given to all infants from the age of 4 days. The concentrations of calcium, phosphorus and phosphatase in the serum showed variations toward those seen in active ...
S, EEK, L H, GABRIELSEN, S, HALVORSEN
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Nature, 1948
IN his address to the Seventh Congress of Biological Chemistry in Liege on October 3–6, 1946, Dr. H. D. Kay summarized some experiments on feeding pigs with yeast, carried out during the War at the National Institute for Research in Dairying in Reading1.
T J, DE MAN, E, HOFF-JØRGENSEN
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IN his address to the Seventh Congress of Biological Chemistry in Liege on October 3–6, 1946, Dr. H. D. Kay summarized some experiments on feeding pigs with yeast, carried out during the War at the National Institute for Research in Dairying in Reading1.
T J, DE MAN, E, HOFF-JØRGENSEN
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Postgraduate Medicine, 1965
A brief survey of rickets is presented. Specific biochemical determinations establish whether rachitic changes are primary or secondary to systemic disease. If no underlying disease is present, the most likely diagnosis is vitamin D-refractory rickets. The difficulties in management of this form of the disease are emphasized.
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A brief survey of rickets is presented. Specific biochemical determinations establish whether rachitic changes are primary or secondary to systemic disease. If no underlying disease is present, the most likely diagnosis is vitamin D-refractory rickets. The difficulties in management of this form of the disease are emphasized.
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