Results 11 to 20 of about 82,393 (306)
Rickets in Children: An Update
Biomedicines, 2021 Rickets refers to a deficient mineralization of the growth plate cartilage, predominantly affecting longer bones. Despite the fact that preventive measures are available, it is still a common disease worldwide; nutritional rickets, due to vitamin D ...
Cristina Gentile, Francesco Chiarelli
doaj +2 more sources
Alkaline phosphatase in clinical practice in childhood: Focus on rickets
Frontiers in Endocrinology, 2023 Serum alkaline phosphatase (ALP) and its isoenzymes reflect bone metabolism: ALP increases the ratio of inorganic phosphate to pyrophosphate systemically and facilitates mineralization as well as reduces extracellular pyrophosphate concentration, an ...
Giuseppe Cannalire +6 more
doaj +2 more sources
BMC Pediatrics, 2018 Background There’s abundant sunshine in the tropics but severe rickets is still observed. Nutritional rickets is associated with an increased risk of acute lower respiratory infections.
Thereza Piloya +5 more
doaj +2 more sources
Abstract 155: Vitamin D dependent rickets type II: Our experience and systematic review
Indian journal of endocrinology and metabolism, 2022 Background: Hereditary vitamin D resistant rickets, is a rare autosomal recessive disease caused by variants affecting VDR gene. We aimed to describe our experience and systematically review the world literature. Objective: To evaluate the phenotypic and
Manjunath
semanticscholar +1 more source
Approach to Hypophosphatemic Rickets
Journal of Clinical Endocrinology and Metabolism, 2022 Hypophosphatemic rickets typically presents in infancy or early childhood with skeletal deformities and growth plate abnormalities. The most common causes are genetic (such as X-linked hypophosphatemia), and these typically will result in lifelong ...
Sarah A Ackah, E. Imel
semanticscholar +1 more source
Rickets guidance: part II—management
Pediatric nephrology (Berlin, West), 2022 Here, we discuss the management of different forms of rickets, including new therapeutic approaches based on recent guidelines. Management includes close monitoring of growth, the degree of leg bowing, bone pain, serum phosphate, calcium, alkaline ...
D. Haffner +3 more
semanticscholar +1 more source
Frontiers in Endocrinology, 2021 X-linked hypophosphatemic rickets (XLH) is the commonest inherited form of rickets. It is caused by an impaired regulation of fibroblast growth factor 23 (FGF23) due to a PHEX gene mutation, which leads to reduced tubular reabsorption of phosphate and ...
G. Baroncelli, S. Mora
semanticscholar +1 more source
Rickets guidance: part I—diagnostic workup
Pediatric nephrology (Berlin, West), 2021 Rickets is a disease of the growing child arising from alterations in calcium and phosphate homeostasis resulting in impaired apoptosis of hypertrophic chondrocytes in the growth plate.
D. Haffner +3 more
semanticscholar +1 more source
Ectopic Calcification and Hypophosphatemic Rickets: Natural History of ENPP1 and ABCC6 Deficiencies
Journal of Bone and Mineral Research, 2021 Generalized arterial calcification of infancy (GACI) is a rare disorder caused by ENPP1 or ABCC6 variants. GACI is characterized by low pyrophosphate, arterial calcification, and high mortality during the first year of life, but the natural course and ...
Carlos R Ferreira +14 more
semanticscholar +1 more source
Hereditary hypophosphatemic rickets with hypercalciuria
Definitions, 2020 An autosomal recessive form of hypophosphatemic rickets caused by inactivating mutation(s) in the SLC34A3 gene, encoding sodium-dependent phosphate transport protein 2C, a protein involved in maintenance of inorganic phosphate concentration in the kidney.
semanticscholar +1 more source