Results 61 to 70 of about 82,393 (306)

Vitamin D‐induced mechanisms in cancer prevention and therapy: Recent advances and future opportunities

Animal Models and Experimental Medicine, EarlyView.
Vitamin D, traditionally known to promote calcium and bone health, is being explored for its role in cancer prevention and treatment through its influence on cell proliferation, differentiation, apoptosis, and immune response. The vitamin D receptor (VDR) regulates gene expression and interacts with key signaling pathways such as Wnt/β‐catenin, MAPK ...
D. Prasanth, Pathan Amanulla Khan, Jamal‐E‐Fatima, Trupti Pratik Durgawale, Falak Arjumand Siddique, Sharuk L. Khan, Azmath Farhana, Uttam Prasad Panigrahy, Mohammed Abdul Aziz shahid, Mohammed Sayeed, Md. Faysal   +10 more
wiley   +1 more source

Rickets and osteomalacia

Medicine, 2001
Abstract Rickets is the clinical consequence of impaired mineralization of bone matrix throughout the growing skeleton in children, whilst osteomalacia is the result of this disturbance after the growth plates have fused in adults. The three major causes of rickets and osteomalacia are vitamin D deficiency, renal tubular dysfunction, and abnormalities
Whyte, M, Thakker, R
openaire   +4 more sources

Human interparietal bones: Examination of existing classification schemes and development of a graphic library depicting variations

The Anatomical Record, EarlyView.
Examples from the graphic library depicting morphologies of interparietal bones, ossicles at lambda, mendosal sutures, and intrasutural ossicles. Abstract Due to its complex ossification during development, the superior region of the human occipital bone is a frequent site of supernumerary bones known as interparietal bones.
Melissa D. Clarkson, Rhian R. Dunn, Joseph T. Hefner, Holly A. Long, Micayla C. Spiros   +4 more
wiley   +1 more source

Celiac disease presenting as rickets in Saudi children

Annals of Saudi Medicine, 2013
BACKGROUND AND OBJECTIVES: Rickets is commonly seen as a sign of malabsorption like celiac disease if it is not treated appropriately with vitamin D and calcium supplements.
Asaad Assiri, Anjum Saeed, Ahmed AlSarkhy, Mohammed Issa El Mouzan, Wael El Matary   +4 more
doaj   +1 more source

Recent Utilization of Pediatric Extrapolation and Modeling and Simulation Approaches in Pediatric Drug Development in Japan

The Journal of Clinical Pharmacology, EarlyView.
Abstract In Japan, the percentage of approved drugs with pediatric indications increased to 30% in 2010‐2015, but no further increase was observed through 2020. The Ministry of Health, Labor, and Welfare in Japan presented draft future directions to promote pediatric drug development, where the modeling and simulation (M&S) approach was introduced as a
Akinori Nakashima, Akihide Tsujimoto, Masako Saito, Jun Takeda, Makiko Natori, Satoshi Shoji   +5 more
wiley   +1 more source

Relationship between rickets and incomplete distal renal tubular acidosis in children

Italian Journal of Pediatrics, 2010
Background In the Sub Saharan Africa Rickets has now been established to be due primarily to calcium deficiency and sometimes in combination with vitamin D deficiency. The main thrust of management is calcium supplementation with or without vitamin D. An
Oduwole Abiola O, Giwa Olayiwola S, Arogundade Rasheed A   +2 more
doaj   +1 more source

CYP3A4 mutation causes vitamin D–dependent rickets type 3

Journal of Clinical Investigation, 2018
Genetic forms of vitamin D–dependent rickets (VDDRs) are due to mutations impairing activation of vitamin D or decreasing vitamin D receptor responsiveness.
Jeffrey D. Roizen, Dong Li, L. O’Lear, M. Javaid, N. Shaw, P. Ebeling, Hanh H. Nguyen, C. Rodda, K. Thummel, T. Thacher, H. Hakonarson, M. Levine   +11 more
semanticscholar   +1 more source

Acute onset neurological deficits and hypocalcaemia associated with nutritional secondary hyperparathyroidism in three juvenile servals (Leptailurus serval)

Australian Veterinary Journal, EarlyView.
Nutritional secondary hyperparathyroidism is a metabolic disorder caused by an imbalance in calcium homeostasis and is typically associated with the feeding of a calcium‐deficient diet. Nutritional secondary hyperparathyroidism has been reported in domestic species, including cats and dogs, as well as captive carnivores and wildlife including lions ...
JL Austen, JW Wheelahan, J O'Dwyer, S Beths, NL Rourke, BR Gardner   +5 more
wiley   +1 more source

Evaluation of diagnostic potential of CD38 in rickets

Molecular and Cellular Probes
Background: Rickets occurs in infants and children (aged 2 months to 3 years), compromising their skeletal development and damaging nervous, hematopoietic, immune, and other system functions.
Yongjie Xia, Xiaoshuo Ye, Wei Chen, Chao You, Chao Deng, Yibiao Zhou   +5 more
doaj   +1 more source

Limits, Limitations, and Necessity in Margaret Macdonald

European Journal of Philosophy, EarlyView.
ABSTRACT I offer a contribution to recent work on Margaret Macdonald (1903–1956), a prolific though largely unknown figure in the history of analytic philosophy who applied Wittgensteinian insights to a broad range of issues. Here I examine the development of Macdonald's views with respect to idealism and conventionalism, through the application of a ...
Oliver Thomas Spinney
wiley   +1 more source