Establishment of a replicating plasmid in Rickettsia prowazekii. [PDF]
PLoS ONE, 2012 Rickettsia prowazekii, the causative agent of epidemic typhus, grows only within the cytosol of eukaryotic host cells. This obligate intracellular lifestyle has restricted the genetic analysis of this pathogen and critical tools, such as replicating ...
David O Wood +8 more
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Discovery of a protective Rickettsia prowazekii antigen recognized by CD8+ T cells, RP884, using an in vivo screening platform. [PDF]
PLoS ONE, 2013 Rickettsia prowazekii has been tested for biological warfare due to the high mortality that it produces after aerosol transmission of very low numbers of rickettsiae.
Michal Gazi +6 more
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Involvement of Pore Formation and Osmotic Lysis in the Rapid Killing of Gamma Interferon-Pretreated C166 Endothelial Cells by Rickettsia prowazekii [PDF]
Tropical Medicine and Infectious Disease, 2022 Rickettsia prowazekii, the bacterial cause of epidemic typhus in humans, proliferates mainly within the microvascular endothelial cells. Previous studies have shown that murine macrophage-like RAW264.7 cells are rapidly damaged if they are pretreated ...
Jenifer Turco
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Inactivation of SAM-methyltransferase is the mechanism of attenuation of a historic louse borne typhus vaccine strain. [PDF]
PLoS ONE, 2014 Louse borne typhus (also called epidemic typhus) was one of man's major scourges, and epidemics of the disease can be reignited when social, economic, or political systems are disrupted.
Yan Liu +4 more
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Genotyping Rickettsia prowazekii Isolates [PDF]
Emerging Infectious Diseases, 2008 We developed a typing method that can differentiate 8 strains of Rickettsia prowazekii into 7 genotypes. This method can be used to type and trace the origin of R. prowazekii isolated from samples collected during epidemics after a bioterrorism attack.
Yong Zhu +4 more
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Fluorescence Activated Cell Sorting of Rickettsia prowazekii-Infected Host Cells Based on Bacterial Burden and Early Detection of Fluorescent Rickettsial Transformants. [PDF]
PLoS ONE, 2016 Rickettsia prowazekii, the causative agent of epidemic typhus, is an obligate intracellular bacterium that replicates only within the cytosol of a eukaryotic host cell.
Lonnie O Driskell +4 more
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BMC Microbiology, 2006 Background Among the 17 genes encoding autotransporter proteins of the "surface cell antigen" (sca) family in the currently sequenced Rickettsia genomes, ompA, sca5 (ompB) and sca4 (gene D), have been extensively used for identification and phylogenetic ...
Raoult Didier +3 more
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TlyC, a conserved hemolysin in Rickettsia, contributes to spotted fever pathogenesis in mice [PDF]
Microbiology SpectrumRickettsia circulates between mammalian hosts and hematophagous arthropod vectors by exploiting their intracellular environment. With advances in rickettsial genetic tools, recent studies have identified novel molecular mechanisms involved in Rickettsia ...
Luke Helminiak +3 more
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Analysis of convergent gene transcripts in the obligate intracellular bacterium Rickettsia prowazekii. [PDF]
PLoS ONE, 2011 Termination of transcription is an important component of bacterial gene expression. However, little is known concerning this process in the obligate intracellular pathogen and model for reductive evolution, Rickettsia prowazekii.
Andrew Woodard, David O Wood
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Adipose tissue serves as a reservoir for recrudescent Rickettsia prowazekii infection in a mouse model. [PDF]
PLoS ONE, 2010 Brill-Zinsser disease, the relapsing form of epidemic typhus, typically occurs in a susceptible host years or decades after the primary infection; however, the mechanisms of reactivation and the cellular reservoir during latency are poorly understood ...
Yassina Bechah +4 more
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