Results 61 to 70 of about 3,644 (172)

Mitochondrial Dysfunction in Ehrlichia canis Infection

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Transmitted by tick vectors, Ehrlichia canis (E. canis) is a Gram‐negative, obligate intracellular bacterium of zoonotic concern that infects both canine and human hosts. Its pathogenesis centers on the targeting of mononuclear phagocytes, where it establishes an intracellular niche by suppressing phagolysosomal fusion and evading immune detection ...
Xishuai Tong, Jing Jiang, Liu Yang, Yunying Liu, Li Chen, Xiaohui Fu, Gengsheng Yu, Naineng Chen, Shuo Tian, Siyang Huang, Shucheng Huang, Jameel Ahmed Buzdar, Xiang Chen, Zongping Liu, Francesco Mira   +14 more
wiley   +1 more source

Effect of immunosuppression on Rickettsia rickettsii infection in guinea pigs [PDF]

Infection and Immunity, 1978
The role of the immune response in the pathogenesis of Rickettsia rickettsii infection in guinea pigs was investigated by immunosuppression, using antilymphocyte serum. Twenty guinea pigs were inoculated with R. rickettsii, Sheila Smith strain, on day 0. Fifteen animals received antilymphocyte serum on days --1, 0, 2, 4, and 6.
D H, Walker, F W, Henderson
openaire   +2 more sources

A new spotted fever group Rickettsia genotype in Haemaphysalis leporispalustris from Maine, USA

Ticks and Tick-Borne Diseases
Spotted fever group (SFG) rickettsioses are increasingly recognized worldwide as threats to public health. Rickettsia rickettsii, Rickettsia parkeri, and Rickettsia rickettsii subspecies californica cause spotted fever rickettsioses, including Rocky ...
Guang Xu, Elissa Ballman, Nolan Stamborski, Eric L. Siegel, Patrick Pearson, Stephen M. Rich   +5 more
doaj   +1 more source

Drug Design and Delivery for Intracellular Bacteria: Emerging Paradigms

Drug Development Research, Volume 86, Issue 8, December 2025.
ABSTRACT Intracellular bacteria exploit host cell niches, such as lysosomes, phagosomes, cytosol, entire cells, and even erythrocytes, to evade immune clearance and escape conventional antibiotics. These environments pose numerous therapeutic challenges, including crossing host cell membranes, navigating endosomal trafficking, tolerating acidic and ...
Babatunde Ibrahim Olowu, Maryam Ebunoluwa Zakariya, Abdulmuheez Abiola Abdulkareem, Olalekan Toheeb Okewale, Muhammad Halima Idris, Halimah Oluwayemisi Olayiwola   +5 more
wiley   +1 more source

In vitro guinea pig leukocyte reactions to Rickettsia rickettsii [PDF]

Infection and Immunity, 1977
The presence of cell-mediated immunity in Rocky Mountain spotted fever-infected guinea pigs was determined by two in vitro assays: whole blood lymphocyte transformation (LT) and macrophage migration inhibition. Increased LT was detected as early as 1 week in guinea pigs infected with Rickettsia rickettsii and treated with oxytetracycline and was ...
R H, Kenyon, M S, Ascher, R A, Kishimoto, C E, Pedersen   +3 more
openaire   +2 more sources

Ecological dynamics of blacklegged ticks, vertebrate hosts, and associated zoonotic pathogens in northeastern forests

Ecosphere, Volume 16, Issue 12, December 2025.
Abstract Specific host‐tick interactions in temperate forest systems influence variation in density and infection prevalence of nymphal blacklegged tick (Ixodes scapularis). The density of infected nymphs (DIN), which is the product of nymphal infection prevalence (NIP) and density of questing nymphs (DON), influences the risk of human exposure to tick‐
Shannon L. LaDeau, Kelly Oggenfuss, Alexander Schmidt, Saravanan Thangamani, Richard S. Ostfeld   +4 more
wiley   +1 more source

Rocky Mountain Spotted Fever, Panama

Emerging Infectious Diseases, 2007
We describe a fatal pediatric case of Rocky Mountain spotted fever in Panama, the first, to our knowledge, since the 1950s. Diagnosis was established by immunohistochemistry, PCR, and isolation of Rickettsia rickettsii from postmortem tissues.
Dora Estripeaut, María Gabriela Aramburú, Xavier Sáez-Llorens, Herbert A. Thompson, Gregory A. Dasch, Christopher D. Paddock, Sherif Zaki, Marina E. Eremeeva   +7 more
doaj   +1 more source

Automated identification of spotted‐fever tick vectors using convolutional neural networks

Medical and Veterinary Entomology, Volume 39, Issue 4, Page 829-841, December 2025.
We evaluate the performance of convolutional neural networks (CNN) AlexNet, ResNet‐50 and MobileNetV2 for the automated identification of tick species capable of transmitting spotted fever. CNNs achieved accuracy rates of ~90% in identifying ticks and showed sensitivities of 59%–100% according to species, sex, position or image resolution.
Isadora R. C. Gomes, Vinícius L. Miranda, José Fabrício C. Leal, Igor P. Oliveira, Paula J. Silva, Karla Bitencourth, Claudio M. Rodrigues, Liege R. Siqueira, Marcelo B. Labruna, Gilberto S. Gazeta, Marinete Amorim, Rodrigo Gurgel‐Gonçalves   +11 more
wiley   +1 more source

Rickettsia rickettsiiinAmblyomma patinoiTicks, Colombia [PDF]

Emerging Infectious Diseases, 2015
Para el editor: Rickettsia rickettsii es el agente etiológico de la fiebre maculosa de las Montañas Rocosas (RMSF), una rickettsiosis transmitida por garrapatas altamente letal restringida al hemisferio occidental (1,2). En Colombia, R. rickettsii se informó por primera vez durante la década de 1930, cuando 62 (95%) de 65 personas afectadas murieron de
Álvaro A. Faccini‐Martínez, Francisco B. Costa, Tatiana E. Hayama-Ueno, Alejandro Ramírez-Hernández, Jesús A. Cortés-Vecino, Marcelo B. Labruna, Marylin Hidalgo   +6 more
openaire   +3 more sources

INFECCIÓN POR RICKETTSIAS EN EL NOROESTE DE ARGENTINA

Revistas Argentina de Medicina, 2018
Las rickettsias son entidades clínicas emergentes y reemergentes del tipo zoonótico, de la familia Rickettsiaceae. Son un género de bacterias intracelulares obligadas transmitidas por diferentes vectores artrópodos hematófagos como garrapatas, pulgas ...
Alejandra P Sánchez, Mauricio Herrera Verduguez, Claudia Caucota, Marisa Ortega, Marianela Borgatta, Ricardo A León de la Fuente   +5 more
doaj   +2 more sources