Results 171 to 180 of about 33,887 (293)

Gravity‐Tolerant In‐Flight 3D Bioprinting Enabled by Stereolithography for Space Tissue Engineering

Advanced Science, EarlyView.
A flight‐compliant, closed stereolithographic 3D bioprinting system enables robust fabrication of acellular and cell‐laden hydrogel constructs under varying gravitational conditions, including microgravity and hypergravity phases. Printed structures retain dimensional fidelity and high‐resolution features, while cell viability remains high ...
Bianca Lemke, Matthias R. Kollert, Tobias Lam, Tobias Thiele, Nicolas Göbel, Lisa R. Köhn, Gabriela Korus, Lutz Kloke, Georg N. Duda   +8 more
wiley   +1 more source

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

Smooth and shape-constrained quantile distributed lag models. [PDF]

Biometrics
Jin Y, Molstad AJ, Wilson A, Antonelli J.   +3 more
europepmc   +1 more source

Pearl‐Like Bioinspired Coating Enables Regulation of Mg Degradation for Osteoporotic Bone Repair

Advanced Science, EarlyView.
In this study, inspired by pearl architecture, we developed a layered Ca–P “brick” and Fn‐mimetic peptide “mortar” coating on Mg alloys. The Ca–P layer moderates corrosion and offers mineral cues, while the peptide enhances adhesion and regulates immune‐vascular responses.
Siming Zhang, Tao Zhang, Yuan Chen, Nikolaos Kourkoumelis, Mo Chen, Jiale Dong, Zhenyu Li, Yanling Zhou, Ning Li, Chen Zhu, Xifu Shang, Jiaxiang Bai, Xianzuo Zhang   +12 more
wiley   +1 more source

Robust estimation methods for addressing multicollinearity and outliers in beta regression models. [PDF]

Sci Rep
Olaluwoye OT, Lukman AF, Alrasheedi MA, Nzomo WN, Farghali RA.   +4 more
europepmc   +1 more source

Pacinian Corpuscle‐Inspired Strain Conversion Enables Ultrasensitive, Linear, and Broad‐Range Piezoelectric Sensing for Cardiovascular Health Monitoring

Advanced Science, EarlyView.
A bioinspired piezoelectric sensor mimicking Pacinian corpuscles is developed to enable ultrasensitive and linear pressure sensing. A multilayer grooved architecture converts normal pressure into in‐plane strain, delivering high sensitivity, wide linear range, and efficient energy harvesting, enabling high‐fidelity wrist pulse monitoring and ...
Qi Yang, Zhongqian Song, Shengjie Liu, Yingming Ma, Weiyan Li, Huijun Kong, Cuiyu Liu, Yu Bao, Li Niu   +8 more
wiley   +1 more source

Asymptotic theory of in-context learning by linear attention. [PDF]

Proc Natl Acad Sci U S A
Lu YM, Letey M, Zavatone-Veth JA, Maiti A, Pehlevan C.   +4 more
europepmc   +1 more source

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

Advanced Science, EarlyView.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély, István Narozsny, Levente Szarka, Daniel V. Veres, Peter Csermely, Dávid Keresztes   +5 more
wiley   +1 more source

A new Liu-type estimator in a mixed Poisson regression model. [PDF]

Sci Rep
Alqasem OA, Hammad AT, El-Raouf MMA, Yousuf AM, Gemeay AM.   +4 more
europepmc   +1 more source

A Janus‐Like Bio‐Inspired Strategy for 3D‐Printed Bimetallic Metamaterials with Excellent Thermal‐Protection and Load Bearing Capacity

Advanced Science, EarlyView.
A Janus‐like bio‐inspired strategy is proposed for integrally 3D‐printed bimetallic metamaterials. Inspired by shell bilayers, a heat‐resistant AlSiFeMnNiMg alloy and a SiC‐reinforced AlSi10Mg with different SiC volume fractions are arranged as an architected pair.
Zhicheng Dong, Wei Cheng, Yu He, Ben Jia, Xiaopeng Wan, Heyuan Huang   +5 more
wiley   +1 more source