Results 111 to 120 of about 49,976 (250)

Inhibition of late sodium current prevents pathological hyperactivation of calcium/calmodulin‐dependent protein kinase IIδ in a murine model of acute doxorubicin‐related cardiotoxicity

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Doxorubicin (DOX) is a highly effective anthracycline, whose clinical application for cancer is limited by cardiotoxicity. The mechanisms underlying doxorubicin‐induced toxic cardiomyopathy (DICM) involve electrophysiological remodelling with intracellular Na+ overload because of increased late INa and hyperactivation of
Anna‐Lena Feder   +7 more
wiley   +1 more source

Right Aortic Arch with Bicarotid Trunk and Aberrant Left Subclavian Artery. [PDF]

open access: yesIndian J Radiol Imaging, 2023
Sharma A, Rana P, Naganur SH, Singhal M.
europepmc   +1 more source

Targeted delivery of the CB2 receptor agonist JWH‐133 via VCAM‐1‐functionalised nanoparticles attenuates atherosclerosis and reveals sex‐specific therapeutic outcomes

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Atherosclerosis, a chronic inflammatory disease characterised by lipid accumulation and endothelial dysfunction, remains a leading cause of cardiovascular morbidity and mortality. While cannabinoid 2 (CB2) receptor agonists show therapeutic promise in preclinical studies, their systemic application is hindered by poor ...
Lucía Martín‐Navarro   +3 more
wiley   +1 more source

Right aortic arch

open access: yes, 2014
Judah Goldschmiedt, Benjamin Taragin
openaire   +2 more sources

Von Willebrand Factor and ADAMTS13 in Relation to Atherosclerosis in the General Population: The Rotterdam Study

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Background Higher von Willebrand factor (VWF) levels and lower ADAMTS13 activity are linked to increased risk of atherosclerotic cardiovascular disease, but their association with atherosclerosis burden, a potential underlying mechanism, remains unclear.
Mitra Nekouei Shahraki   +4 more
wiley   +1 more source

Surgical management of congenital extrahepatic portosystemic shunt in a pony foal

open access: yesEquine Veterinary Education, EarlyView.
Summary A five‐month‐old Welsh pony filly was admitted to the Veterinary Teaching Hospital of the University of Helsinki due to neurological signs. Clinicopathological findings showed elevated ammonium and bile acid levels. Computed tomography revealed an aberrant vessel originating from an enlarged splenic vein, leading to the right azygos vein ...
N. Hakonen   +4 more
wiley   +1 more source

Sclerostin regulates bone morphogenetic protein (BMP) bioavailability through interactions with BMP complexes and fibrillin microfibrils

open access: yesThe FEBS Journal, EarlyView.
Sclerostin (SOST) is a multifunctional extracellular modulator of BMP and Wnt signaling. SOST binds with high affinity to fibrillin‐1 and fibrillin‐2, localizing it to fibrillin microfibrils and regulating its extracellular bioavailability. Fibrillin‐bound SOST cannot engage BMP‐7 prodomain (PD) complexes, revealing a competitive mechanism that ...
Annkatrin Correns   +11 more
wiley   +1 more source

Catheter Ablation: Evolution and Efficiencies

open access: yesJournal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT The present review includes a discussion the goals and pitfalls of efficiency in the medical profession, a historical perspective on the evolution of catheter ablation in the field of electrophysiology (EP), and the data regarding the relationship between efficiency and outcomes in the EP lab. Focus on efficacy is critical to maximize resource
Aravind G. Kalluri, Bradley P. Knight
wiley   +1 more source

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