Results 31 to 40 of about 33,468 (260)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Masquerading Bundle Branch Block in a Patient with Heart Failure in Nigeria

International Medical Case Reports Journal, 2020
Olumide A Akinyele, Michael O Balogun, Rasaaq A Adebayo, Oladiipo A Olanipekun, Anthony O Akintomide, Oyeronke T Williams, Obafemi S Adesanya Cardiology Unit, Department of Medicine, Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile-Ife,
Akinyele OA, Balogun MO, Adebayo RA, Olanipekun OA, Akintomide AO, Williams OT, Adesanya OS   +6 more
doaj  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Case Report: Complete atrioventricular block in an elderly patient with acute pulmonary embolism

Frontiers in Cardiovascular Medicine
IntroductionMultiple abnormal electrocardiographic findings have been documented in patients experiencing acute pulmonary embolism. Although sinus tachycardia is the most commonly encountered rhythmic disturbance, subsequent reports have highlighted ...
Moojun Kim, Chang-ok Seo, Hangyul Kim, Hye Ree Kim, Kyehwan Kim, Min Gyu Kang, Jeong Rang Park   +6 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Absent right bundle branch block: Is it a clue of pre-excitation in Ebstein's anomaly?

Indian Heart Journal, 2016
A 14-year-old male with a history of symptomatic tachycardia was referred for ablation. Sinus rhythm electrocardiogram was not showing any pre-excitation.
Pranil Bhalchandra Gangurde, Abhay Tidake, Hetan Shah, Ajay Mahajan, Yash Lokhandwala, Pratap Nathani   +5 more
doaj   +1 more source

Clinical characteristics and the severity of coronary atherosclerosis of different subtypes of bundle‐branch block

Annals of Noninvasive Electrocardiology, 2022
Background Right bundle‐branch block (RBBB) and left bundle‐branch block (LBBB) play a role in the pathogenesis and progression of coronary artery disease (CAD).
Tongjian Zhu, Mingxian Chen, Wei Hu, Benfang Wang, Hong Jiang   +4 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Vector electrocardiographic alterations after percutaneous septal ablation in obstructive hypertrophic cardiomyopathy: possible anatomic causes

Arquivos Brasileiros de Cardiologia, 2002
OBJECTIVE: Analyze the dromotropic disturbances (vector-electrocardiographic), and the possible anatomic causes, provoked by selective alcohol injection in the septal branch, for percutaneous treatment, of obstructive hypertrophic cardiomyopathy. METHODS:
Pérez Riera Andrés Ricardo, Cano Silvia Judith Fortunato de, Cano Manuel Nicolás, Gimenez Vera Márcia L., Fleury Neto Luciano Augusto de Padua, Sousa José Eduardo M. R.   +5 more
doaj  

A case report of a rare and distinctive pacing pattern during left bundle branch pacing in a child with third-degree atrioventricular block following ventricular septal defect repair

Frontiers in Cardiovascular Medicine
After repair of a ventricular septal defect (VSD), atrioventricular conduction block frequently occurs, often requiring pacemaker implantation. Left bundle branch pacing (LBBP) is a physiological pacing modality and has become the preferred pacing ...
Yue Bao, Wenwen Chen, Qingquan Zhang, Hongwei Han   +3 more
doaj   +1 more source