Results 101 to 110 of about 868,255 (306)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Resistance and Street Theatre: Democratizing the Space and Spatializing the Democracy

Sanglap: Journal of Literary and Cultural Inquiry, 2015
The present paper explores how the practice of street theatre by staging resistance not only exercises the right to resist but strengthens the democratic values and institutions.
Rahul Kamble
doaj  

Diagnostic Stewardship Trends and Antimicrobial Resistance Profiles of Bacteria Isolated in Zambia: A Five-Year Retrospective Study (2020–2024)

Antibiotics
Background/Objectives: The right diagnostic tests, for the right patient, at the right time, are key to optimising antimicrobial use (AMU) and preventing antimicrobial resistance (AMR).
Joseph Yamweka Chizimu, Aubrey Chichonyi Kalungia, Steward Mudenda, Zoran Muhimba, Chileshe Lukwesa, Webrod Mufwambi, Amon Siame, Kelvin Mwangilwa, Priscilla Gardner, Jimmy Hangoma, Victor Daka, Chikwanda Chileshe, Ntombi B. Mudenda, Maisa Kasanga, Misheck Shawa, Herman Chambaro, Duncan Chanda, Taona Sinyawa, Bertha Chibwe, Kaunda Kaunda, Kaunda Yamba, O-Tipo Shikanga, Freddie Masaninga, Mpela Chibi, Sandra Diana Mwadetsa, Doreen Mainza Shempela, Mwendalubi Albert Hadunka, Samson Mukale, Andrew Bambala, Malambo Mutila, Loveness Sakalimbwe, Fred Mulako Simwinji, Geoffrey Mainda, Chie Nakajima, Ruth Nakazwe, Fusya Goma, Nyambe Sinyange, Yasuhiko Suzuki, John Bwalya Muma, Roma Chilengi   +39 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Fontan Physiology without Surgery: A Hemodynamic Paradox in RV Endomyocardial Fibrosis

Journal of the Indian Academy of Echocardiography & Cardiovascular Imaging
Endomyocardial fibrosis (EMF) is a form of restrictive cardiomyopathy that often involves the right ventricle (RV). In rare cases, advanced RV EMF can mimic the hemodynamics of surgically created Fontan circulation, a phenomenon known as acquired Fontan ...
Jassim Kariyakkarantavida Puthiyapurayil, Suryanath Kalapurakal Raveendranathan, Sajeer Kalathingathodika, Rajesh Gopalan Nair   +3 more
doaj   +1 more source

Right-Wing Authoritarianism between Different Religions and Its Negative Effect on Attitudes and Behaviors toward COVID-19 Policies in Brazil

Socius
Some conservative governments denied the COVID-19 pandemic crisis, inducing their supporters to go against sanitary measures. However, could individuals aligned with such political beliefs jeopardize their health due to ideological conviction?
Luciano Rossoni, Clayton Pereira Gonçalves, Mônica Pereira da Silva   +2 more
doaj   +1 more source

Hemodynamic rounds: Transcatheter creation of ventricular septal defect in pulmonary arterial hypertension with suprasystemic pressures

Annals of Pediatric Cardiology
This hemodynamic round section deals with severe pulmonary arterial hypertension with suprasystemic pulmonary artery pressures in a patient who underwent delayed surgical correction of the double-outlet right ventricle with a large subaortic ventricular ...
Kothandam Sivakumar
doaj   +1 more source