Results 61 to 70 of about 740,145 (358)

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

open access: yesMolecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam   +9 more
wiley   +1 more source

Absence of Witness Protection is a Threat to Fair Trial as Envisaged Under the Constitution of Pakistan, 1973

open access: yes, 2020
The purpose of this research is to analyze the causes of non-implementation of witness protection laws in Pakistan and their effects on the right of a fair trial.
A. Uddin, Liaquat Ali
semanticscholar   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

open access: yesMolecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka   +10 more
wiley   +1 more source

International experience in legal support of freedom of speech on the Internet

open access: yesLaw. Human. Environment, 2023
The relevance of the studied subject lies in the fact that freedom of speech is a fundamental human right that should be ensured at the legislative level.
L. Golovko, V. Ladychenko, O. Kapplová
doaj   +1 more source

The Fairness of a Fair Trial: Not Guilty Pleas and the Right to Effective Assistance of Counsel [PDF]

open access: yes, 2009
The pervasiveness of plea bargaining in our modern justice system has led too many courts to conclude that the Sixth Amendment right to effective assistance of counsel applies to not guilty pleas. This Note argues that, although the United States Supreme
Tinmouth, Leigh
core  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Розумний строк судового розгляду та концепція керування часом судового розгляду

open access: yesПроблеми Законності, 2016
Постановка проблеми. Розумний строк судового розгляду є невід’ємним елементом права на справедливий судовий розгляд, закріпленого у п. 1 ст. 6 Європейської конвенції про захист прав людини та основоположних свобод.
Тетяна Андріївна Цувіна
doaj   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Algorithms in Judicial Environments – the Importance of Identifying Relevant Judicial Decision-Making Stage

open access: yesTeisė, 2020
The paper examines the application of Artificial Intelligence systems in the judicial environments. It provides an outline of a typology of different algorithms applicable in judicial environments depending on judicial decision-making stage.
Donatas Murauskas
doaj   +1 more source

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