Results 181 to 190 of about 87,415,308 (291)

THE RIGHT TO SELF-DEFENSE AND THE RIGHT TO BEAR ARMS: SELF-DEFENSE IS A HUMAN RIGHT; THE RIGHT TO BEAR ARMS IS A LEGAL OPTION/RIGHT

International Journal of Social Sciences and Management Review, 2020
openaire   +1 more source

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source

Preliminary Development and Assessment of a Multiplex Assay for Human Papillomavirus Antibody Detection Using Commercial L1 Proteins. [PDF]

J Clin Lab Anal
Aslanabadi A, Karimi M, Powell L, Schumaker L, Shutt A, Hojabri M, Abbasi R, Bentzen SM, Cullen KJ, Crowell TA, Nowak RG, Sajadi MM.   +11 more
europepmc   +1 more source

Real and personal property of the Department of Defense.

Report year for 1954 ends Dec. 31; for 195?- June 30.Mode of access: Internet.Vols. for 1954- prepared by the Department's Assistant Secretary of Defense (Comptroller) under a variant form of name: Office of the ...
United States. Dept. of Defense., United States. Assistant Secretary of Defense (Comptroller)   +1 more
core  

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

A case of central migration of a prosthetic femoral head following bipolar hemiarthroplasty treated with conversion to total hip arthroplasty using an acetabular reinforcement ring. [PDF]

J Orthop Case Rep
Hisahiro K, Kobayashi H, Hashimoto T, Nakamura K, Horiuchi K.   +4 more
europepmc   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

The value of a prophage-borne defense system in phage-phage competition. [PDF]

PLoS Comput Biol
Meir Y, Wingreen NS.
europepmc   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

Advanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta, Janhavi Nistane, Abhishek Sose, Harikrishna Sahu, Rampi Ramprasad   +4 more
wiley   +1 more source

An Older Adult With Abdominal Fullness. [PDF]

J Am Coll Emerg Physicians Open
Lai CY, An YC.
europepmc   +1 more source