Results 41 to 50 of about 1,516,698 (313)
Three Errors in the Substance View's Defense [PDF]
, 2018 According to the theory of intrinsic value and moral standing known as the “substance view,” all human beings have intrinsic value, full moral standing and, with these, a right to life.
Lovering, Rob
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Fighting Back: Crime, Self-Defense, and the Right to Carry a Handgun [PDF]
, 1997 Ten years ago this month, a controversial "concealed- carry" law went into effect in the state of Florida. In a sharp break from the conventional wisdom of the time, that law allowed adult citizens to carry concealed firearms in public.
Jeffrey Snyder
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Civil Challenges to the Use of Low-Bid Contracts for Indigent Defense [PDF]
, 2000 In recent years, increasing attention has been directed to the problem of adequate representation for indigent criminal defendants. While overwhelming caseloads and inadequate funding plague indigent defense systems of all types, there is a growing ...
Lemos, Margaret H.
core +2 more sources
A Penal Colony for Bad Lawyers [PDF]
, 2018 In this article I set out what I believe is an extreme and unconventional way to discipline egregiously bad lawyers. For starters, I think it might be useful to survey briefly the kinds of lawyering conduct currently subject to disciplinary sanctions ...
Gershman, Bennett L.
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Defense statement in the misdemeanor procedure [PDF]
Glasnik Advokatske komore Vojvodine, 2019 The author analyzes a written defense statement as a special form ofthe right to defense of the defendant in the misdemeanor proceedings. After defining the conditions for the application of this type of defense, the author points out the specificity of ...
Jeličić Mladen
doaj
THE RIGHT TO STATE SERVICE IN THE MODERN MEASURE
Baltic Journal of Economic Studies, 2022 The article is dedicated to the accomplishment of a great number of meals, which stand for the defense of the right to state service for the protection of digitalization processes, as if the state service and the normatively established methods for the ...
Liubov Bila-Tiunova, Roman Savchuk
doaj +1 more source