Results 31 to 40 of about 879,007 (253)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Motives behind Finnish student teachers’ career choices [PDF]

We acknowledge funding for the project from the Finnish Ministry of Education and Culture under the project Right to Learn – Skills to Teach (OKM/38/592/2018) https://www.hamk.fi/projects/right-to-learn-skills-to-teach/?lang=en.Peer ...
Räty, Kaisa, Education in the North, Takala, Marjatta, Sirkko, Riikka, Raudasoja, Anu   +4 more
core   +1 more source

RIGHT OF THE CHILD TO PLAY ::from conception to implementation.

, 2023
This book provides a vital and original investigation into, and critique of, the situation facing the realisation of the child's right to play. The right to play has been referred to as a forgotten right - forgotten by States implementing the Convention ...
Lott, Naomi, Lott, Naomi.
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

The impact of digitalisation on the right to education

, 2023
Notwithstanding the many opportunities and remarkable long-term potential afforded by the digitalization of education and the integration of ICT tools, these technologies also generate challenges, and deepen existing inequalities.
Meiselles, M.
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Remote teaching to ensure equal access to education in rural schools [PDF]

, 2020
An impending challenge in today’s school is to ensure that all students have access to an equal education, which should in turn improve social and economic conditions for both individual and society (Lundahl, 2016).
J Ola Lindberg, Jakob Billmayer, Billmayer, Jakob, From, Jörgen, Jörgen From, Fanny Pettersson, Billmayer, Jakob,, Education in the North, From, Jörgen,, Lindberg, J Ola,, Pettersson, Fanny,, Lindberg, J Ola, Lindberg, J. Ola, Pettersson, Fanny   +13 more
core   +1 more source