Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
The consequences of flexible work for health: are we looking at the right place? [PDF]
, 2002 Joan Benach +3 more
openalex +1 more source
Substance Use Disorder Treatment Decision Aid for Adults in Chittenden County Vermont [PDF]
, 2019 Substance Abuse Disorders (SUDs) are a prevalent public health concern in both the national and local arena resulting in millions of dollars in pubic health costs and loss of life.
McLeod, Elizabeth V
core +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Public health and the law. The right to psychiatric treatment.
, 1968 W J Curran
openalex +1 more source
Health bodies defend their right to access patient data [PDF]
, 2002 Phyllida Brown
openalex +1 more source
Editor\u27s Updates from the College [PDF]
, 2009 CAMHB Gets a New Name. The College for Advanced Management of Health Benefits has been renamed The College for Value-Based Purchasing of Health Benefits (CVBP).
Goldfarb, Neil I.
core +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Finding the right words: breaking bad news in sudden death: P A Evans. Produced in collaboration with the Bereavement Group of the A&E Department, Leicester Royal Infirmary and Leicestershire Constabulary. (video 28 minutes; 75+VAT). Available from Health Education Video Unit, Freepost LE6493, Leicester LE5 2ZJ, UK [PDF]
, 2002 C A McLauchlan
openalex +1 more source