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Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

open access: yesFEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr   +5 more
wiley   +1 more source
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Right to Health

Dictionary of Global Bioethics, 2021
The right to health refers to everyone enjoying the highest attainable standard of physical and mental health. This right is not new in that it was already mentioned as a fundamental right in the constitution of the WHO in 1946. The 1948 Universal Declaration of Human Rights also mentioned health as part of the right to an adequate standard of living ...
Henk ten Have   +1 more
openaire   +3 more sources

The Right to Health Care

The Right to Health Care: Ethical Considerations, 2022
distress and had significant functional impairment. This brief transdiagnostic intervention improved both outcomes compared with enhanced usual care, and improvements were sustained over time.
E. Kluge
semanticscholar   +1 more source

PROTECTION OF THE RIGHT TO HEALTH DURING THE PERIOD OF ARMED CONFLICT: THE EXPERIENCE OF UKRAINE

Access to Justice in Eastern Europe, 2022
This article deals with the protection of the right of the civilian population and medical workers to health. The issue of rights violations arises in connection with the armed conflict between the Russian Federation and Ukraine, which has been ongoing ...
T. Mykhailichenko, Y. Zabuha
semanticscholar   +1 more source

The Right to Health

The Lancet, 2018
The right to health and health services is generally framed as the right to the highest attainable standard of health. Like other human rights, the right to health confers to all people specific entitlements and imposes duties on governments to protect and promote them. It reflects a broadened sense of governmental responsibility for the welfare of its
openaire   +4 more sources

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