Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy
Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla +15 more
wiley +1 more source
Frailty index predicts the risk of 17 health outcomes in distinct ways: prospective findings from the Moli-sani Study. [PDF]
Bracone F +14 more
europepmc +1 more source
Space‐Time Coding Conformal Metasurfaces for Multifrequency Beam Steering and Shaping
Space‐time coding conformal metasurfaces enable dynamic wave control on curved surfaces by combining programmable spatial patterns with temporal modulation. This study shows that a single conformal aperture can independently manipulate multiple frequency components, achieving multifunctional beam shaping and steering, with implications for ...
Filippo Pepe +8 more
wiley +1 more source
LUMIN: an open source dynamic reconfigurable lightboard for neurorehabilitation and athletic training. [PDF]
Peterson ZD, Stefanovic F.
europepmc +1 more source
A Geometrically Transient Platform for Bioelectronic Implants
Minimally invasive bioelectronic implants often compromise performance for smaller sizes. To resolve this optimization dilemma, a wireless bioelectronic implant with a transient geometry is introduced (MiFi). The origami‐inspired device miniaturizes up to sixfold for syringe insertion and autonomously unfolds post‐implantation.
Selin Olenik +13 more
wiley +1 more source
Walk in our shoes: older homeless women's perceptions of the challenges of navigating streets and shelter life. [PDF]
Gonyea JG, Melekis K.
europepmc +1 more source
Resolving Heterogeneity of Targeted Lipid Nanoparticles Through Solution‐Based Biophysical Analyses
AF4‐UV‐DLS‐MALS‐SAXS resolves previously inaccessible targeted lipid nanoparticle (tLNP) subpopulations that differ in size, shape, and composition. Correlation of subpopulation‐resolved biophysical properties with in vivo RNA delivery reveals that targeted placental transfection is associated with distinct tLNP subpopulations rather than ensemble ...
Hannah C. Geisler +14 more
wiley +1 more source
The effect of housing system and broiler breed on meat quality<sup>1</sup>. [PDF]
Caceres JC +9 more
europepmc +1 more source
Topology‐Orchestrated Multi‐physical Energy Control in Turtle Shell‐Inspired Metamaterials
A turtle shell‐inspired lattice metamaterial efficiently manages acoustic, fluid‐thermal, and mechanical energy flows simultaneously. The unique hybrid‐coupling architecture achieves superior sound attenuation via pore‐cavity resonance, facilitates effective airflow transport, and maximizes mechanical energy absorption through multistage cell ...
Xi Wang +3 more
wiley +1 more source

