Results 201 to 210 of about 2,576,175 (309)

Pitch as a Shared Code for Music and Speech: Behavioral and Neural Evidence From Stroke Patients. [PDF]

Brain Behav
Sihvonen AJ, Makkonen T, Särkämö T.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Traumatic left ventricular apical pseudoaneurysm in a young woman: a rare and life-threatening condition. [PDF]

Eur Heart J Case Rep
Zouhri O, Hajji Y, Mezalek AT, Cheikhaoui Y.   +3 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Modelling cognitive outcomes in the UK Biobank: Education, noradrenaline and frontoparietal networks. [PDF]

PLoS One
Bravo-Merodio L, Olley-Williams JA, Russ D, Gkoutos G, Brosnan MB, Bellgrove MA, Chechlacz M.   +6 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Treatment of Hemifacial Spasm With Endovascular Stenting of the Vertebral Artery. [PDF]

Neurosurg Pract
Feygin M, Wong MS, Zhang A, Viswanathan A, Tanweer O.   +4 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Using Quantitative EEG to Manage Blood Pressure in a Child With Carotid ECMO Cannulation: Case Report and Proof of Concept. [PDF]

J Child Neurol
Pierson N, Lopez N, Li Y, Nijagal A, Finlay K, Sacks LD, Numis AL, Fox CK, Caffarelli M.   +8 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source