Results 201 to 210 of about 2,720,449 (296)

An Infusible Decellularized Extracellular Matrix Material Binds to Vasculature in Infarcted Myocardium and Induces Pro‐Reparative Gene Expression Following Acute Myocardial Infarction Through Inherent Avidity and Bioactive Signaling

Advanced Science, EarlyView.
To better characterize an infusible extracellular matrix (iECM) material, we applied size‐based fractionation to separate out components into two major fractions. We characterized these fractions to understand how material properties such as composition, morphology, and biochemical properties affect bioactive effects in the context of acute myocardial ...
Michael B. Nguyen, Alexander Chen, Quincy Lyons, Van K. Ninh, Maxwell C. McCabe, Colin Luo, Benjamin D. Bridgelal, Connor Uhre, Julian Cheng, Kate E. Reimold, Selena Cao, Kirk C. Hansen, Kevin R. King, Karen L. Christman   +13 more
wiley   +1 more source

Ischemic Postconditioning Protects Aged Myocardium Against Ischemia/Reperfusion Injury by Regulating Mitochondrial Dynamics via piR‐4913

Advanced Science, EarlyView.
A tiny RNA tips the scales of cardiac injury in aging. piR‐4913 recruits OGT to Drp1 and drives its O‐GlcNAcylation at Thr604, promoting excessive mitochondrial fission that aggravates ischemia‐reperfusion injury. Ischemic postconditioning silences this pathway to restore mitochondrial balance and protect the aged myocardium, revealing piR‐4913 as a ...
Xiangyu Zhao, Yanchun Li, Nan Li, Juan Zhang, Xiaolong Ma, Fei Yang, Ruihan Long, Yining Tian, Yichen Wang, Shengchao Ma, Huiping Zhang, Yideng Jiang   +11 more
wiley   +1 more source

Beyond the right ventricle: assessment of the left ventricular function in pulmonary hypertension. [PDF]

Front Med (Lausanne)
Xie Y, Wang T, Tan Y, Li J.
europepmc   +1 more source

Stroke‐Heart Syndrome: Mechanisms, Temporal Phenotypes, and Diagnostic Reasoning

Advanced Science, EarlyView.
Stroke‐heart syndrome describes new or worsened cardiac abnormalities after acute stroke. This Review defines its clinical boundaries, traces autonomic, inflammatory, endothelial, and supply‐demand mechanisms across time, and proposes provisional phenotypes that integrate lesion location, premorbid cardiac substrate, serial biomarkers ...
Fa Lin, Jian Lyu, Yanci Liu, Zhiyuan Feng, Jie Bao, Wenxiong Song, Bingcheng Zhu, Minghao Liu, Jionghao Xue, Jiadi Weng, Jiani Zhang, Jizong Zhao, Xiaolin Chen, Bin Dong   +13 more
wiley   +1 more source

Angiogenic Potential of Endothelial Cells in Response to the Stiffness and Anisotropy of Right Ventricle Mimetic Scaffolds. [PDF]

Bioengineering (Basel)
Wang Y, Nguyen-Truong M, Chinnadurai R, Hematti P, Wagner WR, Wang Z.   +5 more
europepmc   +1 more source

A UBE3A‐UTX Proteostasis‐Epigenetic Axis Governs Hypothalamic Energy Homeostasis

Advanced Science, EarlyView.
Ubiquitin protein ligase E3A (UBE3A) regulates hypothalamic energy homeostasis and promotes degradation of the histone demethylase UTX (KDM6A). Neuronal UBE3A loss increases susceptibility to diet‐induced obesity and is accompanied by UTX accumulation, reduced histone H3 lysine 27 trimethylation, and altered endoplasmic reticulum stress‐responsive gene
Junekyoung Lee, Jaeyoung Yoo, Young A. Kim, Zhuodu Wei, Yunseo Lee, Woo‐Jeong Shon, Je Kyung Seong, Seunghee Lee   +7 more
wiley   +1 more source

Traumatic Compression of a Percutaneous Valve-in-Valve Right Ventricle-to-Pulmonary Artery Conduit in a Young Athlete. [PDF]

JACC Case Rep
Kansakar S, Holloway B, Cowie L, Bowater S, Hudsmith L, Arif S, Constantine A, Moody W, Clift P, Al-Sakini N.   +9 more
europepmc   +1 more source

A Single Volatile VO2 Memristor Enabling Neuromorphic Perception, Learning, and Computing

Advanced Electronic Materials, EarlyView.
A single volatile VO2 memristor fabricated via atomic layer deposition is demonstrated as a multifunctional neuromorphic device enabled by intrinsic threshold‐switching dynamics. The device reproduces neuron‐like integration and firing, short‐timescale associative learning, temporal ECG pattern classification, and nociceptive responses to electrical ...
Bingkai Ding, Bohao Ding, Omesh Kapur, Yisong Han, Richard Beanland, Kai Sun, C. H. (Kees) de Groot, Ruomeng Huang   +7 more
wiley   +1 more source

Proteomics Defines Shared and Divergent Alterations in the Right Atrium and Right Ventricle in Porcine Right Heart Failure. [PDF]

Pulm Circ
Prins SE, Sternbach J, Mendelson JB, Markowski T, Higgins L, Carney JP, Tollison W, Choudhary G, Prins KW.   +8 more
europepmc   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source