Results 121 to 130 of about 431,616 (383)

Right ventricular mechanical pattern in patients undergoing mitral valve surgery: a predictor of post‐operative dysfunction?

ESC Heart Failure, 2020
The PREPARE‐MVR study (PRediction of Early PostoperAtive Right vEntricular failure in Mitral Valve Replacement/Repair patients) sought to investigate the alterations of right ventricular (RV) contraction pattern in patients undergoing mitral valve ...
M. Tokodi, E. Németh, B. Lakatos, E. Kispál, Z. Tősér, L. Staub, K. Rácz, Á. Soltész, S. Szigeti, T. Varga, J. Gal, B. Merkely, A. Kovács   +12 more
semanticscholar   +1 more source

Right Heart Remodeling in Patients with End-Stage Alcoholic Liver Cirrhosis: Speckle Tracking Point of View [PDF]

, 2019
BACKGROUND: Data regarding cardiac remodeling in patients with alcoholic liver cirrhosis are scarce. We sought to investigate right atrial (RA) and right ventricular (RV) structure, function, and mechanics in patients with alcoholic liver cirrhosis.
Braun, Alexander, Cuspidi, Cesare, Heinzel, Frank, Koeckritz, Francisca von, Pieske, Burkert, Schmuck, Rosa B., Tadic, Marijana, Teegen, Eva M., Zhang, Kun   +8 more
core   +1 more source

Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1

Advanced Science, EarlyView.
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo, Yuanyuan Li, Wensheng Li, Tongrui Wu, Yi Liu, Yacoubou Abdoul Razak Mahaman, Jianzhi Wang, Rong Liu, Wei Liu, Hui Shen, Xiaochuan Wang   +10 more
wiley   +1 more source

Impact of Right Ventricular Systolic Dysfunction on Outcome in Aortic Stenosis

Circulation Cardiovascular Imaging, 2020
Supplemental Digital Content is available in the text. Background: Pulmonary hypertension is an established outcome predictor in patients with aortic stenosis (AS), but the prognostic impact of right ventricular dysfunction has not been well studied ...
Y. Bohbot, P. Guignant, D. Ruşinaru, Maciej Kubala, S. Maréchaux, C. Tribouilloy   +5 more
semanticscholar   +1 more source

Assessment of left atrial volume before and after pulmonary thromboendarterectomy in chronic thromboembolic pulmonary hypertension. [PDF]

, 2014
BackgroundImpaired left ventricular diastolic filling is common in chronic thromboembolic pulmonary hypertension (CTEPH), and recent studies support left ventricular underfilling as a cause.
Auger, William R, Blanchard, Daniel G, DeMaria, Anthony N, Kimura, Bruce J, Madani, Michael M, Marston, Nicholas A, Raisinghani, Ajit B, Strachan, G Monet   +7 more
core   +3 more sources

Mechanical Stress Induced NOX2 Promotes Endothelial Dysfunction in Ventilator‐Induced Lung Injury: Potential Treatment with Quercetin

Advanced Science, EarlyView.
Abnormal mechanical stretch induced by mechanical ventilation (MV) disrupts endothelial junctions via the NOX2/ROS/CaMKII/ERK1/2 axis both in human aortic endothelial cells (HAECs) in vitro and in ventilator‐induced lung injury (VILI) in mice. Quercetin, an antioxidant predicted to bind to NOX2, can effectively prevent mechanical stretch‐induced ...
Tao Jiang, Yabing Zhang, Zhiye Guo, He Ren, Weiyi Hu, Qingping Yao, Yunlong Huo, Yingxin Qi, Kai Huang   +8 more
wiley   +1 more source

Disconnect between Fibrotic Response and Right Ventricular Dysfunction.

American Journal of Respiratory and Critical Care Medicine, 2019
Rationale: Remodeling and fibrosis of the right ventricle (RV) may cause RV dysfunction and poor survival in patients with pulmonary hypertension. Objectives: To investigate the consequences of RV fibrosis modulation and the accompanying cellular changes
S. Crnkovic, B. Egemnazarov, R. Damico, L. Marsh, B. Nagy, P. Douschan, Kwame Atsina, T. Kolb, S. Mathai, J. Hooper, B. Ghanim, W. Klepetko, F. Fruhwald, D. Lassner, A. Olschewski, H. Olschewski, P. Hassoun, G. Kwapiszewska   +17 more
semanticscholar   +1 more source

EBBP‐Mediated Integrated Stress Response Attenuates Anthracycline‐Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes

Advanced Science, EarlyView.
EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen, Can Chen, Yichen Wu, Yinxue Xia, Ruijie Luo, Jiangcheng Shu, Long Chen, Zhaohui Wang, Cheng Wang, Kai Huang   +9 more
wiley   +1 more source

A Human Engineered Heart Tissue‐Derived Lipotoxic Diabetic Cardiomyopathy Model Revealed Early Benefits of Empagliflozin

Advanced Science, EarlyView.
This study develops a human engineered heart tissue‐derived model of diabetic cardiomyopathy that accurately replicates the dynamic changes in the structural, contractile, and electrophysiological properties of the myocardium. Furthermore, this model is used to confirm the direct protective effects of empagliflozin on the heart through an SGLT2 off ...
Lin Cai, Yuxin Zhao, Zilong Li, Liping Xiao, Yifan Wu, Shiya Wang, Qian Liu, Yida Ye, Yuxuan Guo, Donghui Zhang   +9 more
wiley   +1 more source

Preoperative right ventricular strain as an early predictor of perioperative cardiac failure in patients undergoing mitral surgery: An exploratory study

Health Science Reports
Objectives This study's primary purpose was to demonstrate the correlation of preoperative right ventricular free‐wall longitudinal strain (RVFWLS) and pre‐/postsurgical variation in strain (delta strain) with the clinical and echocardiographic diagnosis
Alessandro Russo, Elisa Bergamini Viola, Alessia Gambaro, Gianfranco Di Gennaro, Diego Fanti, Alessandro Devigili, Marcello Ceola Graziadei, Gabriele Brognoli, Luisa Corubolo, Jacopo Rama, Anita Zanin, Vittorio Schweiger, Katia Donadello, Enrico Polati, Leonardo Gottin   +14 more
doaj   +1 more source