Results 251 to 260 of about 1,320,475 (425)

Repurposing With Purpose: Treatment of Bachmann–Bupp Syndrome With Eflornithine and Implications for Other Polyaminopathies

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Rare diseases impact approximately 1 in 10 people worldwide, and yet, less than 5% of all rare diseases currently have an approved treatment option available. This is due to many challenges unique to rare diseases, including small, diverse patient populations, the cost of drug development that is not proportionate to the number of patients who
Caleb P. Bupp, Elizabeth A. VanSickle, Julianne Michael, Chad R. Schultz, Kelly Nguyen, Melissa Hoefer, Surender Rajasekaran, André S. Bachmann   +7 more
wiley   +1 more source

QT and Tpeak‐Tend interval variability: Predictive electrical markers of hospital stay length and mortality in acute decompensated heart failure. Preliminary data

Clinical Cardiology, Volume 45, Issue 12, Page 1192-1198, December 2022., 2022
Abstract Background As previously reported, an increased repolarization temporal imbalance induces a higher risk of total/cardiovascular mortality. Hypothesis The aim of this study was to assess if the electrocardiographic short period markers of repolarization temporal dispersion could be predictive of the hospital stay length and mortality in ...
Gianfranco Piccirillo, Federica Moscucci, Myriam Carnovale, Gaetano Bertani, Ilaria Lospinuso, Ilaria Di Diego, Andrea Corrao, Teresa Sabatino, Giulia Zaccagnini, Davide Crapanzano, Pietro Rossi, Damiano Magrì   +11 more
wiley   +1 more source

Invited letter concerning: Right ventricular function after transatrial versus transventricular repair of tetralogy of Fallot

, 1992
Ross M. Ungerleider
openalex   +1 more source

A safe and simple method of preserving right ventricular function during implantation of a left ventricular assist device [PDF]

, 2001
Matthias Loebe, Evgenij Potapov, Ralf Sodian, Michael Kopitz, George P. Noon   +4 more
openalex   +1 more source

Metabolic alterations in human pulmonary artery smooth muscle cells treated with PDGF‐BB

Animal Models and Experimental Medicine, EarlyView.
Metabolic abnormalities are considered to play a key regulatory role in vascular remodeling of pulmonary arterial hypertension. We analyzed the metabolome in the culture supernatants of human pulmonary artery smooth muscle cells (PASMC) during the malignant proliferation phenotype transition via a targeted metabolomics method. Significant and extensive
Meng‐Jie Zhang, Jie‐Jian Kou, Hong‐Da Zhang, Xin‐Mei Xie, Yun‐Feng Zhou, Ping Yuan, Xiao‐Bin Pang, Lu‐Ling Zhao, Jing Qiu, Yang‐Yang He   +9 more
wiley   +1 more source

Survival benefit of overweight patients undergoing MitraClip® procedure in comparison to normal‐weight patients

Clinical Cardiology, Volume 45, Issue 12, Page 1236-1245, December 2022., 2022
Long‐term survival stratified for weight classes illustrated by Hazard plot for patients treated with MitraClip® implantation stratified for weight classes. Association of weight class compared to normal‐weight with long‐term survival (adjusted for Logistic EuroScore).
Karsten Keller, Martin Geyer, Lukas Hobohm, Alexander R. Tamm, Felix Kreidel, Tobias F. Ruf, Michaela Hell, Volker H. Schmitt, Kevin Bachmann, Sonja Born, Eberhard Schulz, Thomas Münzel, Ralph S. von Bardeleben   +12 more
wiley   +1 more source

Impact of pulmonary hypertension and right ventricular function on outcomes of isolated tricuspid valve surgery. [PDF]

JTCVS Open
Altarabsheh SE, Crestanello JA, Saran N, Daly RC, Dearani JA, Greason KL, Stulak JM, Todd A, Rowse PG, Arghami A, Bagameri G, Villavicencio MA, Schaff HV, Anand V.   +13 more
europepmc   +1 more source

Huge right ventricle–right coronary artery fistula compromising right ventricular function in a patient with pulmonary atresia and intact ventricular septum: A case report [PDF]

, 2001
Masamichi Ono, Shigeaki Otake, Norihide Fukushima, Yoshiki Sawa, Hajime Ichikawa, Koji Kagisaki, Hikaru Matsuda   +6 more
openalex   +1 more source

In vivo toxic and lethal cardiorespiratory effects of a synthetic quaternary ammonium salt derivative of haloperidol in mice

Animal Models and Experimental Medicine, EarlyView.
Hematoxylin–eosin (H&E) stains of the heart, liver, lung, and kidney show acute toxicity. Abstract Background To investigate the toxicity of N‐n‐butyl haloperidol iodide (F2), a quaternary ammonium salt derivative of haloperidol, in mice for potential therapeutic purposes. Methods The acute median lethal dose (LD50) of F2 was determined using the Bliss
Jilin Liao, Binger Lu, Jinhua Yang, Xiaowan Wang, Shuxian Li, Hongbo Fu, Fenfei Gao   +6 more
wiley   +1 more source

Predictive value of HMGB1 for atrial fibrillation recurrence after cryoballoon ablation in paroxysmal atrial fibrillation patients

Clinical Cardiology, Volume 45, Issue 12, Page 1229-1235, December 2022., 2022
Abstract Background Cryoballoon ablation (CBA) is recommended for patients with symptomatic drug refractory paroxysmal atrial fibrillation (pAF). However, substantial atrial fibrillation (AF) recurrence is common during follow‐up. Searching for a potential biomarker representing both myocardial injury and inflammation to identify patients at high risk ...
Xinxin Li, Cuiting Zhao, Meng Li, Hongxiao Yu, Xiping Liu, Qing Zhu, Xiaokun Song, Yonghuai Wang, Bo Yu, Chunyan Ma   +9 more
wiley   +1 more source