Results 171 to 180 of about 2,048,259 (212)

Integrative Analysis of Primary SF3B1 mt Ring Sideroblasts Provides Fundamental Insights into MDS-RS Pathogenesis and Dyserythropoiesis

Blood, 2021
Myelodysplastic syndromes (MDS) constitute a heterogeneous group of clonal hematopoietic stem cell (HSC) disorders characterized by aberrant HSC differentiation, cytopenia, and an increased risk of progression to leukemia. The low-risk subtype MDS with
P. Moura, T. Mortera-Blanco, I. Hofman, G. Todisco, W. Kretzschmar, I. Barbosa, Ann-Charlotte Björklund, G. Walldin, M. Jansson, T. Yoshizato, P. Woll, S. Jacobsen, E. Hellström-Lindberg   +12 more
semanticscholar   +1 more source

Lymphocytopenia predicts shortened survival in myelodysplastic syndrome with ring sideroblasts (MDS‐RS) but not in MDS/MPN‐RS‐T

American journal of hematology/oncology, 2021
REFERENCES 1. Fischer K, Al-Sawaf O, Bahlo J, et al. Venetoclax and obinutuzumab in patients with CLL and coexisting conditions. N Engl J Med. 2019; 380(23):2225-2236. 2. Roberts AW, Davids MS, Pagel JM, et al.
A. Mangaonkar, F. Farrukh, K. Reichard, R. Ketterling, N. Gangat, A. Al-Kali, K. Begna, A. Pardanani, M. Patnaik, A. Tefferi   +9 more
semanticscholar   +1 more source

Comparison of therapy-related myelodysplastic syndrome with ring sideroblasts and de novo myelodysplastic syndrome with ring sideroblasts

Leukemia Research, 2019
Presence of RS is closely associated with SF3B1 mutation in de novo MDS. RS is also present in a subset of therapy-related MDS (t-MDS), but data is not available in t-MDS with RS (t-MDS-RS). Using NGS gene panel, we assessed t-MDS-RS (n = 38) and compared the result with d-MDS-RS (n = 174). Commonly mutated genes were TP53 (56.5%), TET2 (39.1%), SF3B1 (
Zhining Chen, Sa A. Wang, Maitrayee Goswami, Guilin Tang, Mark J. Routbort, Keyur P. Patel, Rajyalakshmi Luthra, L. Jeffrey Medeiros, Chi Young Ok   +8 more
openaire   +2 more sources

Combined Phenotypic and Genotypic Analysis of Ringed Sideroblasts in Acquired Idiopathic Sideroblastic Anemia

Acta Haematologica, 2009
Bone marrow from an 81-year-old male with acquired idiopathic sideroblastic anemia was found to be mosaic for 45, X/46, XY cell lines. Analysis of ringed sideroblasts for the presence or absence of a quinicrine fluorescent Y body indicated that all sideroblastic cells had lost the Y chromosome.
D D, Bennett, W S, Stanley, C B, Johnson
openaire   +2 more sources

Response to erythropoiesis‐stimulating agents in patients with WHO‐defined myelodysplastic syndrome/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN‐RS‐T)

British Journal of Haematology, 2020
To the Editor, In the 2016 iteration of the World Health Organisation (WHO) classification of myeloid neoplasms, myelodysplastic syndrome/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T) has been included as a unique ...
G. Antelo, A. Mangaonkar, G. Coltro, Ajinkya Buradkar, T. Lasho, C. Finke, Ryan M. Carr, M. Binder, N. Gangat, A. Al-Kali, M. Elliott, R. King, M. Howard, M. Melody, W. Hogan, M. Litzow, A. Tefferi, M. Fernández-Zapico, R. Komrokji, M. Patnaik   +19 more
semanticscholar   +1 more source

Variant congenital dyserythropoietic anaemia with ringed sideroblasts

Clinical & Laboratory Haematology, 1985
A family is described with mild anaemia characterized by marked dyserythropoiesis and by prominent ringed sideroblasts. Inheritance is autosomal recessive. Other features include marked microcytosis, poikilocytosis, mild haemolysis, slightly increased haemoglobin A2, bone marrow erythroid hyperplasia and non-specific structural abnormalities of ...
W F, Brien, M J, Mant, W S, Etches
openaire   +2 more sources

Ringed Sideroblasts in Primary Myelodysplasia

Archives of Internal Medicine, 1988
• Among 123 patients with ringed sideroblasts on bone marrow aspirates, 85 had acquired ringed sideroblasts with primary myelodysplasia. The patients were placed in categories modified from the French-American-British classification based on percentages of ringed sideroblasts and myeloblasts in the initial bone marrow.
openaire   +1 more source

The Disappearance of Ring Sideroblasts in Myeloblastic Leukaemia in Remission

Scandinavian Journal of Haematology, 1971
A case of acute myeloblastic leukaemia is described in which ring sideroblasts, in the bone marrow, disappeared after induction of a complete remission.
M T, Shaw, M, Foadi
openaire   +2 more sources

Interaction between ring sideroblasts and treatment with hypomethylating agents (HMA) in patients with refractory anemia with ring sideroblasts.

Journal of Clinical Oncology, 2017
e18559 Background: Myelodysplastic syndromes (MDS) are a group of myeloid neoplasms defined by ineffective hematopoiesis, dysplastic morphologic features, and variable risks of progression to acute myeloid leukemia (AML). Refractory anemia with ring sideroblasts (RARS) is a subtype of MDS defined by < 5% basts and > 15% ring sideroblasts (per ...
Rama Nanah, Darci Zblewski, Rong He, Phuong L. Nguyen, Naseema Gangat, Kebede Begna, Michelle A. Elliott, William J. Hogan, Mrinal Patnaik, Mark Robert Litzow, Aref Al-Kali   +10 more
openaire   +1 more source

Somatic SF3B1 mutations in myelodysplastic syndrome with ring sideroblasts and chronic lymphocytic leukaemia

Journal of Clinical Pathology, 2019
SF3B1 is the largest subunit of the Spliceosome Factor 3b (SF3B) complex and part of the U2 small nuclear ribosomal protein. It functions as an important part of spliceosomal assembly, converting precursor messenger RNA (mRNA) to mRNA ready for ribosomal
A. Foy, M. McMullin
semanticscholar   +1 more source