Results 51 to 60 of about 1,039,950 (226)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Selectively Linkable and Convertible Ring Signature Scheme Based on DLP [PDF]

Jisuanji gongcheng, 2019
Most of the existing linkable and convertible ring signature schemes do not have strong anonymity.To solve this problem,a ring signature scheme based on Discrete Logarithm Problem(DLP) is proposed.The actual signer establishes an association tag by ...
CAO Suzhen,SUN Han,DAI Wenjie,WANG Xiuya
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Tree-Ring Skeleton Plotting by Computer

, 1979
Skeleton plotting is an established manual technique for representing the relative narrowness of tree rings in a single radius. These plots can be used as a visual aid to crossdating.
Cropper, John Philip
core   +4 more sources

Post-Quantum Secure ID-Based (Threshold) Linkable Dual-Ring Signature and Its Application in Blockchain Transactions

Cryptography
Ring signatures are widely used in e-voting, anonymous whistle-blowing systems, and blockchain transactions. However, due to the anonymity of ring signatures, a signer can sign the same message multiple times, potentially leading to repeated voting or ...
Wen Gao, Haoyuan Yao, Baodong Qin, Xiaoli Dong, Zhen Zhao, Jiayu Zeng   +5 more
doaj   +1 more source

The ring signature with adaptability

, 2010
[[abstract]]The concept of ring signature was first introduced by Rivest et al. in 2001. Instead of revealing the actual identity of the message signer, it specifies a set of possible signers (ring members).
Tzu-Chung Chen
core  

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source