Results 251 to 260 of about 557,164 (317)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Estimated adherence to the Dapivirine Vaginal Ring and its associated factors among African women: A systematic review and meta-analysis. [PDF]

PLOS Glob Public Health
Dine RD, Muraca GM, Sadeghirad B, Couban R, Nyambi A, Silva J, Mbuagbaw L.   +6 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

A Negatively Curved Pyrene-Fused Azaacene. [PDF]

Angew Chem Int Ed Engl
Carini M, Martín-Arroyo M, Melle-Franco M, Mateo-Alonso A.   +3 more
europepmc   +1 more source

Thermodynamic and Atomistic Insights into Lignin Solubility from Experimentally Validated Molecular Dynamics Simulations. [PDF]

Biomacromolecules
Hackenstrass K, Solihat NN, Nousiainen P, Österberg M, Florisson S, Wohlert J, Wohlert M.   +6 more
europepmc   +1 more source

Solid-state structure and supra-molecular packing of 1,2-bis-(2-phenyl-1<i>H</i>-benzo[<i>d</i>]imidazol-1-yl)diazene. [PDF]

Acta Crystallogr E Crystallogr Commun
Constantinides CP, Yi JS, Marincean S.
europepmc   +1 more source

Shaping Efficiency: Parametric Design for Schwedler Domes. [PDF]

Materials (Basel)
Ibrahim AFAO, Jeleniewicz K, Piekarczuk A.   +2 more
europepmc   +1 more source