Results 101 to 110 of about 1,159 (179)

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Efficient Direct Recycling of Spent Batteries: Integrated Lithiation and Delamination

Advanced Science, EarlyView.
An integrated process for the delamination and relithiation of spent cathodes, LixNi0.6Co0.2Mn0.2O2 and LixFePO4, under open‐air conditions is proposed. The transition‐metal (Ni) oxidation state in the cathode is reduced by the oxidation of diethylene glycol, facilitating relithiation. Glycol aldehyde formation induces 100% electrode delamination.
Jeonghwan Song, Seok Hyun Song, Dokyeong Han, Jaehyun Noh, Jayoung Kim, Min Jeong Kim, Hayong Song, Jeong‐Sun Park, Jaekook Kim, Jiyoung Ma, Jinju Song, Jung‐Je Woo   +11 more
wiley   +1 more source

High Free‐Volume Imidazole‐Based Ionomers for High‐Temperature Proton Exchange Membrane Fuel Cells

Advanced Science, EarlyView.
High free‐volume imidazole‐based ionomers (PF4IM‐72) enable enhanced phosphoric acid uptake and efficient proton transport, delivering peak power densities of 0.645 W cm−2 at 160 °C and 0.838 W cm−2 at 200 °C in HT‐PEMFCs. This work highlights a promising platform for next‐generation ionomers with improved high‐temperature performance and stability ...
Ge Chao, Hyeon Keun Cho, Chang Yeon Hyun, Shirong Li, Jong Geun Seong, So Young Lee, Nanwen Li, Young Moo Lee   +7 more
wiley   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Bias‐Tunable Two‐Terminal Organic Photodetector for Intelligent Imaging

Advanced Science, EarlyView.
A vertically stacked two‐terminal photodetector with a symmetric donor–acceptor–donor trilayer active exhibits reconfigurable photoresponse with bias‐tunable magnitude and polarity, together with sub‐millisecond response speed and a wide tunable output window.
Sangin Hahn, Sanghoon Park, Seunghyup Yoo   +2 more
wiley   +1 more source

Infinite groups acting on formal power series rings

Journal of Algebra, 1978
Brewer, J., Jooste, T., le Riche, L., Sheridan, M., Martens, E., van Rooyen, W., Müller, A.   +6 more
openaire   +2 more sources

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

De Novo Design of Membrane‐Targeting Antimicrobial Peptides Against Gram‐Negative Bacteria Using a Generative Artificial Intelligence Framework

Advanced Science, EarlyView.
Antimicrobial resistance caused by Gram‐negative bacteria remains difficult to overcome due to the protective outer membrane. To address this challenge, a multi‐condition constrained generative AI framework, GenMTAMP is proposed for de novo membrane‐targeting antimicrobial peptide design by integrating physicochemical and spatial structure descriptors.
Jingxiao Yu, Da‐Wen Sun, QingYi Wei, Yibing Zhang, Jidong Tang, Hongbin Pu   +5 more
wiley   +1 more source

Stress Accumulation Induced by Ion Exchange for Synchronous Modulation of Mode and Wavelength in Microlasers

Advanced Science, EarlyView.
This work demonstrates a paradigm‐shifting strategy to simultaneously achieve broadband wavelength tunability and single‐mode control within a single perovskite microwire structure. Using a facile heating‐assisted solid–solid anion‐exchange strategy, we synthesized phase‐pure CsPbClxBr3‐x microwires that exhibit the widest reported continuous lasing ...
Bingwang Yang, Lingling Sun, Jinhui Wang, Jitao Li, Peng Wan, Daning Shi, Caixia Kan, Mingming Jiang   +7 more
wiley   +1 more source

Unusual Thermally Induced Blueshift and Emission Amplification of Mn2+ Ions Enable Filter‐Free Luminescent Thermal Imaging

Advanced Science, EarlyView.
ABSTRACT The shift from point‐based thermal sensing to filter‐free thermal imaging requires luminescent thermometers that exhibit pronounced and thermally driven spectral changes within spectral regions matching the sensitivity profiles of the red, green and blue (RGB) channels of a digital camera.
Y. Abe, M. Szymczak, J. Zeler, L. Marciniak   +3 more
wiley   +1 more source