Results 161 to 170 of about 8,677 (293)

Ramadan fasting in people with diabetes and chronic kidney disease (CKD) during the COVID-19 pandemic: The DaR global survey. [PDF]

Diabetes Metab Syndr, 2023
Hassanein M, Yousuf S, Ahmedani MY, Albashier A, Shaltout I, Yong A, Hafidh K, Hussein Z, Kallash MA, Aljohani N, Wong HC, Buyukbese MA, Chowdhury T, Fadhila MERZOUKI, Taher SW, Belkhadir J, Malek R, Abdullah NRA, Shaikh S, Alabbood M.   +19 more
europepmc   +1 more source

Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

Advanced Science, EarlyView.
In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang, Nan Liang, Wenbo Li, Shuai Xu, Peng Li, Wanze Ni, Na Li, Sha Han, Ningjing Ou, Haowei Bai, Yuxiang Zhang, Furong Bai, Yifan Sun, Dewei Qian, Xinjie Bu, Erlei Zhi, Ruhui Tian, Yuhua Huang, Jingpeng Zhao, Fujun Zhao, Hao Chen, Zheng Li, Chencheng Yao   +22 more
wiley   +1 more source

Diagnosis and Monitoring of Achalasia Utilizing Point-of-Care Ultrasound (POCUS): A Case Report. [PDF]

Cureus
Linn Y, Han PP, Lim KC, Chong VH.
europepmc   +1 more source

Prevalence and Associated Factors of Diabetic Retinopathy among Type 2 Diabetes Mellitus Patients in Brunei Darussalam: A Cross-sectional Study. [PDF]

Korean J Ophthalmol, 2022
Raja SA, Chong VH, Rahman NA, Shakir LMP, Knights J.   +4 more
europepmc   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Les Miserables

JACC: Case Reports, 2019
Sofian Johar, MA, MB, BChir, PhD
doaj   +1 more source

Efficiency of 2D versus 3D CT scans in maxillofacial trauma: A retrospective study. [PDF]

Bioinformation
Panicker P, George AL, Kumar RM, Srujan Kumar M, Francis F, Peter D.   +5 more
europepmc   +1 more source

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

A cost- effectiveness and resource requirement comparison to optimize renal dialysis policies in Brunei Darussalam. [PDF]

Commun Med (Lond)
Myint AN, Lim CY, Rahim S, Razak LBHA, Othman NIEB, Botwright S, Rattanavipapong W, Teerawattananon Y.   +7 more
europepmc   +1 more source

Diabetes Mellitus and Its Therapy in Brunei Darussalam - A Critical Revisit. [PDF]

Patient Prefer Adherence, 2023
Muhammad Haskani NH, Ming LC, Dhaliwal JS, Wee DVT, Goh BH, Ali M, Shaharuddin S, Goh KW, Goh HP.   +8 more
europepmc   +1 more source