Results 81 to 90 of about 8,677 (293)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Tine Buffel, Sophie Handler and Chris Phillipson (eds.) (2018). Age-Friendly Cities and Communities. A Global Perspective. Great Britain: Policy Press, 300 pp. ISBN 978 1 4473 3131 5 (hardback)

International Journal of Ageing and Later Life, 2018
Not Available.
Shyh Poh Teo
doaj   +1 more source

A ara romana de Vila Velha de Mourão [PDF]

, 2018
Volta a estudar-se, do ponto de vista epigráfico, a ara romana, que fora encontrada, em reaproveitamento, na parede norte da igreja da Vila Velha de Mourão (distrito de Évora, Conventus Pacensis).
Abranches, Paula Barreira, Encarnação, José d', Santos, Heloísa Valente dos   +2 more
core  

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Lápide funerária de Tróia (Conventus Pacensis) [PDF]

, 2017
FICHEIRO EPIGRÁFICO é um suplemento da revista CONIMBRIGA, destinado a divulgar inscrições romanas inéditas de toda a Península Ibérica, que começou a publicar-se em 1982.Estuda-se o fragmento de uma placa funerária de Tróia (concelho de Grândola), que ...
Almeida, João, Encarnação, José d', Pereira, Teresa   +2 more
core  

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Um contributo para a caracterização mecânica e análise sísmica da construção em taipa [PDF]

, 2012
A terra é uma matéria-prima abundante e acessível na natureza, que possibilita uma construção sustentável, em termos ambientais, económicos e sociais. Com um reduzido consumo de energia proporciona um bom conforto, em virtude do seu comportamento térmico
Braga, Alfredo Manuel Gonçalves Silva, Farinha, Maria de Fátima Silva Marques Tavares, Graça, Ana Teresa   +2 more
core  

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Ralstonia solanacearum type III effector RipAS associates with potato type one protein phosphatase StTOPP6 to promote bacterial wilt. [PDF]

Hortic Res, 2023
Wang B, He W, Huang M, Feng J, Li Y, Yu L, Wang Y, Zhou D, Meng C, Cheng D, Tang N, Song B, Chen H.   +12 more
europepmc   +1 more source