Results 101 to 110 of about 15,419,997 (324)

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

A simple overlap angle control strategy for reducing commutation torque ripple in a brushless DC motor drive

Engineering Science and Technology, an International Journal, 2017
A commutation torque ripple is generated in a brushless DC motor due to a finite time taken for current transfer between outgoing phase and incoming phase due to the phase inductance.
Chetan K. Lad, R Chudamani
doaj   +1 more source

A Low Torque Ripple Direct Torque Control Method for Interior Permanent Magnet Motor

Applied Sciences, 2020
This paper proposes a simple method to generate stable voltage commands for permanent magnet synchronous motors to achieve low torque ripple based on space vector modulation direct torque control (SVM-DTC).
Min-Fu Hsieh, Yun-Chung Weng
doaj   +1 more source

Dynamics of aeolian sand ripples

, 2000
We analyze theoretically the dynamics of aeolian sand ripples. In order to put the study in the context we first review existing models. We argue on the local character of sand ripple formation. Using a hydrodynamical model we derive a nonlinear equation
Csahok, Z., Misbah, C., Rioual, F., Valance, A.   +3 more
core   +2 more sources

Ripple effect modelling of supplier disruption: integrated Markov chain and dynamic Bayesian network approach

International Journal of Production Research, 2019
The ripple effect can occur when a supplier base disruption cannot be localised and consequently propagates downstream the supply chain (SC), adversely affecting performance.
Seyedmohsen Hosseini, D. Ivanov, A. Dolgui   +2 more
semanticscholar   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Pressure Wave Propagation Optimization Models for Supply Chain Risk Mitigation

Systems
Supply chain (SC) disruption risk assessment and mitigation have attracted significant attention in both academia and practice. However, existing research predominantly focuses on unidirectional disruption propagation, either forward or backward, despite
Ming Liu, Jiawei Zhang, Yueyu Ding
doaj   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

Mandated Wage Floors and the Wage Structure: New Estimates of the Ripple Effects of Minimum Wage Laws [PDF]

Minimum wage laws have become a key political issue, following on the heels of over 130 successful living wage campaigns around the country. In the debates surrounding these mandated wage floors, one recurring issue has been whether the legislation has ...
Jeannette Wicks-Lim
core  

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source