Results 41 to 50 of about 57,359 (285)

Functional Assays for Measuring the Catalytic Activity of Ribosome Inactivating Proteins

Toxins, 2018
Ribosome-inactivating proteins (RIPs) are potent toxins that inactivate ribosomes by catalytically removing a specific adenine from the α-sarcin/ricin loop (SRL) of the large rRNA.
Yijun Zhou, Xiao-Ping Li, Jennifer N. Kahn, Nilgun E. Tumer   +3 more
doaj   +1 more source

Olive oil and clove oil-based nanoemulsion for topical delivery of terbinafine hydrochloride: in vitro and ex vivo evaluation

Drug Delivery, 2022
In this article, formulation studies for terbinafine hydrochloride nanoemulsions, prepared by high-energy ultrasonication technique, are described. Pseudo-ternary phase diagram was constructed in order to find out the optimal ratios of oil and surfactant/
Uzma Gul, Muhammad Imran Khan, Asadullah Madni, Muhammad Farhan Sohail, Mubashar Rehman, Akhtar Rasul, Leena Peltonen   +6 more
doaj   +1 more source

Antiviral Activity of Ribosome-Inactivating Proteins

Toxins, 2021
Ribosome-inactivating proteins (RIPs) are rRNA N-glycosylases from plants (EC 3.2.2.22) that inactivate ribosomes thus inhibiting protein synthesis. The antiviral properties of RIPs have been investigated for more than four decades.
Lucía Citores, Rosario Iglesias, José M. Ferreras   +2 more
doaj   +1 more source

Approximating Local Homology from Samples [PDF]

, 2013
Recently, multi-scale notions of local homology (a variant of persistent homology) have been used to study the local structure of spaces around a given point from a point cloud sample.
Skraba, Primoz, Wang, Bei
core   +3 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Impact of health system strengthening interventions on child survival in sub-Saharan Africa: a systematic review protocol

Systematic Reviews
Background Strengthening healthcare systems is a practical approach to enhance healthcare delivery and services. Although there has been a rise in the number of health systems strengthening (HSS) interventions in sub-Saharan Africa (SSA), there is ...
Caesar Agula, Ayaga A. Bawah, Patrick O. Asuming, Pearl Kyei, Adriana Biney   +4 more
doaj   +1 more source

Derivation, characterization, and stable transfection of induced pluripotent stem cells from Fischer344 rats. [PDF]

PLoS ONE, 2011
The rat represents an important animal model that, in many respects, is superior to the mouse for dissecting behavioral, cardiovascular and other physiological pathologies relevant to humans.
Mikhail Liskovykh, Ilya Chuykin, Ashish Ranjan, Dina Safina, Elena Popova, Elena Tolkunova, Valentina Mosienko, Julia M Minina, Natalia S Zhdanova, John J Mullins, Michael Bader, Natalia Alenina, Alexey Tomilin   +12 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Who pays more? Exploring cost disparities in medication abortion access across socio-demographic groups in Ghana

International Journal for Equity in Health
Background Medication abortion (MA) may be accessed covertly in private pharmacies and clinics due to abortion-related stigma. Stigmatization may lead to information asymmetry, resulting in price discrimination.
Caesar Agula, Yuliya A. Kulikova, Omkar Patange, Adriana Biney, Michael Kuhn, Pearl Kyei, Patrick Asuming, Ayaya A. Bawah   +7 more
doaj   +1 more source

Study on the Effect of Radiant Insulation Panel in Cavity on the Thermal Performance of Broken-Bridge Aluminum Window Frame

Buildings, 2022
Windows have a great impact on building energy consumption, and the thermal performance of window frames directly affects its energy-saving potential. In this paper, a novel method is proposed to optimize the thermal performance of commercially available
Yanhong Zheng, Pengfei Si, Yin Zhang, Lijun Shi, Changjiajin Huang, Dongsheng Huang, Zhineng Jin   +6 more
doaj   +1 more source