Results 81 to 90 of about 14,369,089 (255)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Computational intelligence algorithms for risk-adjusted trading strategies. [PDF]
, 2008 This paper investigates the performance of trading strategies identified through Computational Intelligence techniques. We focus on trading rules derived by Genetic Programming, as well as, Generalized Moving Average rules optimized through Differential ...
Pavlidis, Efthymios +4 more
core +3 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
A two-tiered approach to the valuation of investment projects adjusted for governance risk [PDF]
This paper sets forth a pair of distinctive contributions to the subject. In the first place, it provides a unified approach to capital investment decisions, by means of a two-tiered framework of analysis.
Rodolfo Apreda
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
A Comparative Study of Venture Capital Performance in the US and Europe
The Journal of Entrepreneurial Finance, 2004 For the past fifty years in the United States, venture capital (VC) has provided initial funding to innovative entrepreneurial enterprises, while the European venture capital industry has only really emerged over the past decade.
Xiaoqing Eleanor Xu
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Risk-adjusted performance of AI-powered portfolios: Evidence on volatility, beta, and returns
Borsa Istanbul ReviewThis paper examines risk-adjusted performance differences across AI-themed investment vehicles using monthly data from 2005 to 2025. We compare four equal-weighted portfolios: AI-powered ETFs, AI-focused thematic ETFs, AI/machine-learning (AIML) stocks ...
Ihlas Sovbetov +2 more
doaj +1 more source
(Value, Risk)-based Performance Evaluation of Manufacturing Processes [PDF]
, 2012 A value/risk -based performance evaluation framework is proposed in the context of manufacturing processes at the industrialization phase of product development.
SHAH, Liaqat +3 more
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