Results 101 to 110 of about 6,477,164 (283)
Risk Assessment Algorithms in Pharmacovigilance: A Review
Безопасность и риск фармакотерапииINTRODUCTION. In the Russian Federation, risk-based approaches/methods to assess the safety of medicinal products have been used since 2016, but existing models based on them are few and applicable mainly to healthcare organizations. This underscores the
T. M. Bukatina
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De Jure, 2023 The increased usage of digital financial products and financial services such as mobile money brought various challenges and opportunities in Zimbabwe during the coronavirus (COVID-19) pandemic.
Howard Chitimira, Elfas Torerai
doaj
, 2019 We develop an approach to risk classification based on quantile contours and allometric modelling of multivariate anthropometric measurements. We propose the definition of allometric direction tangent to the directional quantile envelope, which divides ...
Boghossian, Nansi S. +3 more
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Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Integrating a risk-oriented approach into bank investment management under market volatility
Економіка, управління та адмініструванняIn the current context of heightened financial market volatility and growing instability of the investment environment, the issue of enhancing the efficiency of bank investment management has become increasingly critical.
V. V. Shlonchak
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Toxicology and Biodistribution: The Clinical Value of Animal Biodistribution Studies
Molecular Therapy: Methods & Clinical Development, 2018 Since the human genome decoding, understanding and identification of genetic disturbances behind many diseases, including cancer, are intensively increasing. Scientific and technological advances in this area trigger the search for therapeutic (curative)
Beatriz Silva Lima +1 more
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The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
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Farm Level Risk Assessment Using Downside Risk Measures [PDF]
Recent and presumable future developments tend to increase the risk associated with farming activities. This causes an increasing importance of risk management.
Berg, Ernst, Starp, Michael
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Risk estimation for LCF crack initiation
, 2013 An accurate risk assessment for fatigue damage is of vital importance for the design and service of today's turbomachinery components. We present an approach for quantifying the probability of crack initiation due to surface driven low-cycle fatigue (LCF)
Gottschalk, Hanno +3 more
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Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source