Results 101 to 110 of about 34,840,596 (291)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Sociology of Leisure: Risk and Leisure RLO

, 2010
This RLO is part of “Sociology of Leisure” course. The module discusses some major features of current leisure patterns, but these activities are also central to modern life itself and thus have interests for sociologists.
Dr Dave Harris, MARJON
core  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

An efficient security risk estimation technique for risk-based access control model for IoT

, 2019
The need to increase information sharing in the Internet of Things (IoT) applications made the risk-based access control model to be the best candidate for both academic and commercial organizations. Risk-based access control model carries out a security
Atlam, Hany F., Wills, Gary B., Wills, Gary   +2 more
core   +1 more source

Technological Solutions to Reduce Inter-Column Pressures and Improve Well Reliability

Geotechnics
This article considers the causes of inter-column pressures (ICP) in wells and their impact on operational reliability. The analysis of Karachaganak field well stock for the period from 2001 to 2024 demonstrates that inter-column pressures manifest in a ...
Danabek Saduakassov, Annaguly Deryaev, Anvar Eshmuratov, Ernazar Sanetullaev   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Implicit and explicit risk perception, affect, and trust : an investigation of food "traffic lights" [PDF]

, 2014
Obesity is a health problem in many developed countries and is a growing problem worldwide. In an effort to improve food choices the "traffic lights" nutritional labelling system has been developed.
Burns, Calvin, McCarthy, Tony, Revie, Matthew   +2 more
core   +1 more source

A Risk-Based Regulatory Approach To Autonomous Weapon Systems

Digital Society
Abstract International regulation of autonomous weapon systems (AWS) is increasingly conceived as an exercise in risk management. This requires a shared approach for assessing the risks of AWS. This paper presents a structured approach to risk assessment and regulation for AWS, adapting a qualitative framework inspired by the ...
Blanchard, A, Novelli, C, Floridi, L, Taddeo, M   +3 more
openaire   +2 more sources