Results 161 to 170 of about 34,840,596 (291)

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

A Social Disruptiveness-Based Approach to AI Governance: Complementing the Risk-Based Approach of the AI Act. [PDF]

Sci Eng Ethics
Marchiori S, Hopster JKG, Puzio A, Riemsdijk MBV, Kraaijeveld SR, Lundgren B, Viehoff J, Frank LE.   +7 more
europepmc   +1 more source

Cardiac evaluation of young athletes: Time for a risk-based approach? [PDF]

Clin Cardiol, 2020
MacLachlan H, Drezner JA.
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

The Promise of Evidence-Based Policymaking: Report of the Commission on Evidence-Based Policymaking, Appendices E-H

, 2017
Final report appendices E-H of the Commission on Evidence-Based Policymaking (CEP) containing the information gathered through the commission's survey of federal offices, public meeting materials and presentations, public input-hearing testimony and ...
United States. Commission on Evidence-Based Policymaking
core  

Lessons from Ethiopian pharmaceutical regulation: a risk-based approach to overcome challenges and unlock opportunities. [PDF]

Front Med (Lausanne)
Hassen HK, Mekasha YT, Tegegne AA, Ozalp Y.   +3 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Reply to "Reevaluating thromboprophylaxis in COVID-19 outpatients: the case for a targeted, risk-based approach". [PDF]

Res Pract Thromb Haemost
Di Vece D, Connors JM, Barco S.
europepmc   +1 more source

Feasibility of a Risk-Based Approach to Cataract Surgery Preoperative Medical Evaluation.

JAMA Ophthalmol, 2021
Cuttitta A, Joseph SS, Henderson J, Portney DS, Keedy JM, Benedict WL, Lahti H, Klarr PS, Shtein RM, Lee PP, Kerr E, Mian SI.   +11 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source