Results 121 to 130 of about 31,060,844 (362)
Molecular Oncology, EarlyView.There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes +20 more
wiley +1 more source
Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
wiley +1 more source
An oilspill risk analysis for the Mid-Atlantic Outer Continental Shelf lease area
, 1976 Richard Allmon Smith +2 more
openalex +2 more sources
Doctors' attitudes to risk in difficult clinical decisions: application of decision analysis in hepatobiliary disease. [PDF]
, 1984 A Theodossi +3 more
openalex +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Remote SensingThis study explores the growing application of 3D remote sensing in geohazard studies, particularly for rock slope monitoring. It highlights the use of cost-effective Street View Imagery (SVI) and Unmanned Aerial Vehicles (UAV) through Structure-from ...
Tiggi Choanji +5 more
doaj +1 more source
Sensitivity analysis for seismic risk using a fault rupture model [PDF]
, 1982 Bernice Bender
openalex +1 more source
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source