Results 81 to 90 of about 31,060,844 (362)

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

open access: yesMolecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever   +1 more
wiley   +1 more source

Invasion of Intestinal Cells by Staphylococcus aureus is Mediated by Pyruvate Formate Lyase (Pfl) Protein

open access: yesJournal of Pure and Applied Microbiology, 2019
Staphylococcus aureus is a known enterotoxin-producing foodborne pathogen; however, the invasion mechanism of the bacterium into intestinal cells remains unclear. The aim of this study was to determine whether S.
Sejeong Kim   +8 more
doaj   +1 more source

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink   +6 more
wiley   +1 more source

Experimental Study of Quenching Process During Bottom Reflooding Using “Queen” Test Section

open access: yesAtom Indonesia, 2005
Phenomenon of quenching of hot fuels in core during bottom reflooding following loca event is investigated in order to understand the performance cooling process.
M. Juarsa   +5 more
doaj   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi   +3 more
wiley   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

open access: yesMolecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker   +14 more
wiley   +1 more source

Flood Risk Analysis

open access: yes, 2017
Floods affect more people worldwide than any other natural hazard. Flood risk results from the interplay of a range of processes. For river floods, these are the flood-triggering processes in the atmosphere, runoff generation in the catchment, flood waves traveling through the river network, possibly flood defense failure, and finally, inundation and ...
openaire   +5 more sources

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

open access: yesMolecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen   +13 more
wiley   +1 more source

Duration of Immunity in Cattle to Lumpy Skin Disease Utilizing a Sheep Pox Vaccine

open access: yesVeterinary Sciences
The transmission of lumpy skin disease (LSD) occurs through ticks, mosquitoes, and flies. The most effective way to combat LSD is to conduct large-scale vaccination, covering the entire cattle population with safe and effective vaccines, while ...
Varduhi Hakobyan   +7 more
doaj   +1 more source

A Novel Method for Evaluation of Flood Risk Reduction Strategies: Explanation of ICPR FloRiAn GIS-Tool and Its First Application to the Rhine River Basin

open access: yesGeosciences, 2018
To determine the effects of measures on flood risk, the International Commission for the Protection of the Rhine (ICPR), supported by the engineering consultant HKV has developed a method and a GIS-tool named “ICPR FloRiAn (Flood Risk Analysis ...
Adrian Schmid-Breton   +3 more
doaj   +1 more source

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