Results 131 to 140 of about 1,996,867 (356)
Fuzzy Multicriteria analysis for evaluation of risks in complex engineering projects in the Aeronautical industry [PDF]
, 2008 H. Fukayama +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
An improved approach for flight readiness assessment [PDF]
An improved methodology for quantitatively evaluating failure risk for a spaceflight system in order to assess flight readiness is presented. This methodology is of particular value when information relevant to failure prediction, including test ...
Creager, M. +2 more
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Future air quality and human health benefits of net-zero CO2 emissions pathway in China
Atmospheric Environment: XWhile growing attention has been paid to the co-benefits of climate policies, existing research often lacks granularity in evaluating diverse low-carbon transition strategies and their effects on air pollution and public health, particularly within the ...
Yuhang Zhao +4 more
doaj +1 more source
Ethical Issues in Engineering Models: Personal Reflections [PDF]
I start this contribution with an overview of my personal involvement—as an Operations Research consultant—in several engineering case-studies that may raise ethical questions; these case studies employ simulation models.
Kleijnen, Jack P.C.
core +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Atmospheric Environment: XVolatile organic compounds (VOCs) are key precursors to secondary organic aerosol (SOA) and ground-level ozone, posing significant challenges to air quality and public health in China.
Yuhang Zhao +6 more
doaj +1 more source
Protein O‐glycosylation in the Bacteroidota phylum
FEBS Open Bio, EarlyView.Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns +2 more
wiley +1 more source