Results 141 to 150 of about 1,996,867 (356)

Feasibility study on manganese nodules recovery in the Clarion-Clipperton Zone

open access: yes, 2012
The sea occupies three quarters of the area on the earth and provides various kinds of resources to mankind in the form of minerals, food, medicines and even energy.
Agarwal, Baivau   +4 more
core  

A Novel Proposal To Advance The Discipline And To Quantitatively Safeguard Important Hygienic Bio-Processes [PDF]

open access: yes, 2010
A novel proposal that will significantly advance the discipline of chemical engineering, through an improved understanding of unanticipated process risk, and which will safeguard risk in hygienic bio-processing of foods, water and wastes is presented and
Davey, K.
core  

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

open access: yesFEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul   +3 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

ソフトウェアメトリックデータベースのモデリングと解析 [PDF]

open access: yes, 1999
The main objective of this research is to propose a comprehensive framework for quality and risk management in software development process based on analysis and modeling of software metrics data.
Paul Raymond A.
core  

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

open access: yesFEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani   +7 more
wiley   +1 more source

Risk Analysis and Management in Software Engineering

open access: yesInternational Journal of Recent Technology and Engineering, 2019
Many programming building ventures have high dangers and disappointment rates amid their undertaking life. The undertakings primarily experience the ill effects of dangers created in programming advancement which are for the most part caused by operational dangers, innovative dangers, administration rehearses, hazards in accomplishing client ...
openaire   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

open access: yesFEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp   +13 more
wiley   +1 more source

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