NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao +10 more
wiley +1 more source
Body roundness index as a novel anthropometric predictor of sarcopenia in patients with cancer: a bicontinental cohort study across Chinese and American populations. [PDF]
Lipids Health DisYu Y, Hong Y, Zhang P, Cheng K, Chen B.
europepmc +1 more source
Toward a Stakeholder Perspective on Social Stability Risk of Large Hydraulic Engineering Projects in China: A Social Network Analysis [PDF]
, 2018 Zhengqi He +3 more
openalex +1 more source
Chronic Pain in Parkinson’s Disease: Prevalence, Sex Differences, Regional Anatomy and Comorbidities
Annals of Clinical and Translational Neurology, EarlyView.Chronic pain affected 66.2% of 10,631 individuals with Parkinson's disease, with higher prevalence and severity in females. Pain most often involved the buttocks, lower back, neck, and knees, and was linked to depression, sleep disorders, and osteoarthritis.
Natalia S. Ogonowski +13 more
wiley +1 more source
Machine learning for early prediction of secondary cancer after radiotherapy. [PDF]
Sci RepSadeghi H, Seif F, Khanmohammadi S.
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Olfactory dysfunction is frequently observed in patients with multiple sclerosis (MS); however, its underlying mechanisms remain poorly understood. To date, no studies have directly examined the nasal mucosal microbiota in MS. This study aimed to explore potential relationships among olfactory function, nasal microbiota composition,
Zidan Gao +5 more
wiley +1 more source
Global geo-hazard risk assessment of long-span bridges enhanced with InSAR availability. [PDF]
Nat CommunMalinowska D +4 more
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.
Majid Khalilizad +4 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Managing long COVID in people with multiple sclerosis and related disorders (pwMSRD) is complex due to overlapping symptoms. To address evidence gaps, we evaluated long COVID susceptibility in pwMSRD versus controls and its associations with multi‐domain function and disability.
Chen Hu +15 more
wiley +1 more source
Editorial: Advances and applications of predictive toxicology in knowledge discovery, risk assessment, and drug development. [PDF]
Front PharmacolZhang F +6 more
europepmc +1 more source