Results 91 to 100 of about 6,017,024 (357)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Kaempferol Improves Exercise Performance by Regulating Glucose Uptake, Mitochondrial Biogenesis, and Protein Synthesis via PI3K/AKT and MAPK Signaling Pathways

Foods
Kaempferol is a natural flavonoid with reported bioactivities found in many fruits, vegetables, and medicinal herbs. However, its effects on exercise performance and muscle metabolism remain inconclusive.
Xiaoning Ji, Chaozheng Zhang, Jing Yang, Yaru Tian, Lijuan You, Hui Yang, Yongning Li, Haibo Liu, Deng Pan, Zhaoping Liu   +9 more
doaj   +1 more source

Alameda County Placement Risk Assessment Validation [PDF]

, 2000
The Alameda County Probation Department was awarded a grant from the National Institute of Justice in 1998 to develop a risk assessment for probation placement cases.

core  

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Leveraging Epidemiology to Improve Risk Assessment. [PDF]

, 2011
The field of environmental public health is at an important crossroad. Our current biomonitoring efforts document widespread exposure to a host of chemicals for which toxicity information is lacking.
Burke, Thomas A, Fox, Mary A, Nachman, Keeve E, Rodricks, Joseph V, Sheehan, Mary C, Woodruff, Tracey J   +5 more
core  

Cardiovascular risk assessment [PDF]

South African Family Practice, 2011
Cardiovascular disease remains the leading cause of mortality in the Westernised world. Lifestyle changes and drug therapy can reduce cardiovascular risk. Many interventions such as lipid-lowering therapy reduce relative risk to the same extent irrespective of baseline risk, but the absolute benefit is still highest in those with the highest absolute ...
openaire   +4 more sources

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Chicken or egg? Attribution hypothesis and nocebo hypothesis to explain somatization associated to perceived RF-EMF exposure

Frontiers in Public Health
IntroductionThe aim of this study is to understand the temporal relationship between the somatization usually attributed to RF-EMFs, and to evaluate the attribution hypothesis and the nocebo hypothesis in this context.MethodIn this longitudinal study ...
S. Ariccio, E. Traini, L. Portengen, A. Martens, P. Slottje, R. Vermeulen, A. Huss   +6 more
doaj   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Is there a role for thoracic aortic calcium to fine-tune cardiovascular risk prediction? [PDF]

, 2012
Screening asymptomatic subjects to streamline measures for the prevention of cardiovascular events remains a major challenge. The established primary prevention risk-scoring methods use equations derived from large prospective cohort studies, but further
Birgelen, C. von, Hartmann, M.
core   +3 more sources