Results 151 to 160 of about 16,952,383 (406)
Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations
Molecular Oncology, EarlyView.Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák +12 morewiley +1 more sourceRKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies
Molecular Oncology, EarlyView.RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho +10 morewiley +1 more sourceGlobal, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
The Lancet, 2016 M. Forouzanfar, A. Afshin, Lily T Alexander, H. R. Anderson, Z. Bhutta, S. Biryukov, M. Brauer, R. Burnett, Kelly M. Cercy, F. Charlson, A. Cohen, L. Dandona, Kara Estep, A. Ferrari, J. Frostad, N. Fullman, P. Gething, W. Godwin, Max G Griswold, Simon Iain Hay, Y. Kinfu, H. Kyu, H. Larson, Xiaofeng Liang, Stephen S. Lim, Patrick Y. Liu, Alan D. Lopez, R. Lozano, L. Marczak, G. Mensah, A. Mokdad, M. Moradi-Lakeh, M. Naghavi, B. Neal, M. Reitsma, Gregory A. Roth, J. Salomon, P. Sur, T. Vos, Joseph A Wagner, Haidong Wang, Yi Zhao, Maigeng Zhou, Gunn Marit Aasvang, A. Abajobir, K. H. Abate, C. Abbafati, K. Abbas, F. Abd-Allah, A. Abdulle, S. Abera, Biju Abraham, L. Abu-Raddad, G. Abyu, A. Adebiyi, I. Adedeji, Z. Ademi, A. K. Adou, J. Adsuar, E. Agardh, A. Agarwal, Anurag Agrawal, A. Kiadaliri, O. Ajala, T. Akinyemiju, Z. Al-Aly, K. Alam, N. Alam, S. Aldhahri, R. Aldridge, Z. A. Alemu, R. Ali, A. Alkerwi, F. Alla, P. Allebeck, U. Alsharif, K. Altirkawi, E. A. Martin, N. Alvis-Guzmán, Azmeraw T. Amare, A. Amberbir, A. Amegah, H. Amini, W. Ammar, Stephen M. Amrock, H. Andersen, B. Anderson, C. Antonio, P. Anwari, J. Ärnlöv, A. Artaman, H. Asayesh, R. Asghar, Reza Assadi, S. Atique, Euripide Avokpaho, A. Awasthi, B. Quintanilla, P. Azzopardi, U. Bacha, A. Badawi, M. Bahit, K. Balakrishnan, A. Barać, Ryan Barber, S. Barker-Collo, T. Bärnighausen, S. Barquera, L. Barregard, L. Barrero, S. Basu, C. Batis, S. Bazargan-Hejazi, J. Beardsley, Neeraj Bedi, E. Beghi, B. Bell, M. Bell, A. Bello, D. Bennett, I. Benseñor, A. Berhane, E. Bernabé, B. Betsu, A. Beyene, N. Bhala, A. Bhansali, S. Bhatt, S. Biadgilign, B. Bikbov, D. Bisanzio, E. Bjertness, J. Blore, R. Borschmann, S. Boufous, R. Bourne, M. Brainin, A. Brazinova, N. Breitborde, H. Brenner, D. Broday, T. Brugha, B. Brunekreef, Z. Butt, L. Cahill, Bianca Calabria, Ismael Campos-Nonato, Rosario Cárdenas, D. Carpenter, J. Carrero, Daniel C. Casey, C. Castañeda-Orjuela, Jacqueline Castillo Rivas, R. Castro, F. Catalá-López, Jung-Chen Chang, P. Chiang, Mirriam Chibalabala, Odgerel Chimed-Ochir, V. Chisumpa, Abdulaal Chitheer, J. Choi, H. Christensen, D. Christopher, Liliana G. Ciobanu, M. Coates, Samantha M. Colquhoun, A. C. Manzano, Leslie T. Cooper, Kimberly Cooperrider, Leslie Cornaby, Monica Cortinovis, J. Crump, L. Cuevas-Nasu, A. Damasceno, R. Dandona, S. Darby, P. Dargan, J. D. das Neves, A. Davis, K. Davletov, E. F. de Castro, Vanessa De la Cruz-Góngora, D. de Leo, L. Degenhardt, Liana C. Del Gobbo, B. del Pozo-Cruz, R. Dellavalle, A. Deribew, D. Jarlais, S. Dharmaratne, P. Dhillon, C. Díaz-Torné, D. Dicker, E. Ding, E. Dorsey, Kerrie E. Doyle, T. Driscoll, L. Duan, M. Dubey, B. Duncan, I. Elyazar, A. Endries, S. Ermakov, H. Erskine, B. Eshrati, A. Esteghamati, S. Fahimi, E. J. Faraon, T. Farid, C. Farinha, Andre Faro, M. Farvid, F. Farzadfar, V. Feigin, S. Fereshtehnejad, J. Fernandes, F. Fischer, J. Fitchett, T. Fleming, N. Foigt, Kyle Foreman, F. Fowkes, R. Franklin, Thomas Fürst, N. Futran, E. Gakidou, A. García-Basteiro, T. Gebrehiwot, A. Gebremedhin, J. Geleijnse, B. Gessner, A. Z. Giref, M. Giroud, Melkamu Dedefo Gishu, G. Giussani, S. Goenka, M. Gómez-Cabrera, H. Gómez-Dantés, P. Gona, A. Goodridge, S. Gopalani, C. Gotay, A. Goto, H. Gouda, H. Gugnani, F. Guillemin, Yuming Guo, Rahul Gupta, Rajeev Gupta, R. A. Gutiérrez, J. Haagsma, N. Hafezi-Nejad, D. Haile, G. B. Hailu, Y. Halasa, R. Hamadeh, S. Hamidi, A. Handal, G. Hankey, Y. Hao, H. Harb, S. Harikrishnan, J. Haro, Mohammad Sadegh Hassanvand, T. A. Hassen, Rasmus J Havmoeller, I. Heredia-Pi, N. Hernández-Llanes, P. Heydarpour, H. Hoek, H. Hoffman, M. Horino, N. Horita, H. Hosgood, D. Hoy, M. Hsairi, A. Htet, G. Hu, John J Emmanuel Huang, A. Husseini, S. Hutchings, I. Huybrechts, K. Iburg, B. Idrisov, B. Ileanu, M. Inoue, T. Jacobs, K. Jacobsen, N. Jahanmehr, M. Jakovljevic, H. Jansen, S. Jassal, Mehdi Javanbakht, S. Jayaraman, A. Jayatilleke, S. Jee, P. Jeemon, V. Jha, Ying Jiang, T. Jibat, Ye Jin, C. Johnson, J. Jonas, Z. Kabir, Y. Kalkonde, R. Kamal, H. Kan, A. Karch, C. Karema, Chante Karimkhani, A. Kasaeian, Anil Kaul, N. Kawakami, Dhruv S. Kazi, P. Keiyoro, L. Kemmer, A. Kemp, A. Kengne, A. Keren, C. Kesavachandran, Y. Khader, Abdur Rahman Khan, E. Khan, G. Khan, Y. Khang, S. Khatibzadeh, S. Khera, T. Khoja, J. Khubchandani, C. Kieling, Cho-il Kim, Daniel H. Kim, R. Kimokoti, N. Kissoon, M. Kivipelto, L. Knibbs, Y. Kokubo, J. Kopec, P. Koul, A. Koyanagi, M. Kravchenko, H. Kromhout, H. Krueger, Tiffany Ku, B. K. Defo, R. Kuchenbecker, B. K. Bicer, E. Kuipers, G. Kumar, G. Kwan, D. Lal, R. Lalloo, T. Lallukka, Q. Lan, A. Larsson, A. Latif, A. Lawrynowicz, J. Leasher, J. Leigh, J. Leung, M. Levi, Xiaohong Li, Yichong Li, Juan Liang, Shiwei Liu, B. Lloyd, G. Logroscino, P. Lotufo, R. Lunevicius, Michael F. MacIntyre, M. Mahdavi, M. Majdan, A. Majeed, R. Malekzadeh, D. Malta, Wondimu Ayele Ayele Manamo, C. Mapoma, W. Marcenes, R. Martin, J. Martínez-Raga, F. Masiye, K. Matsushita, R. Matzopoulos, B. Mayosi, J. Mcgrath, M. Mckee, P. Meaney, C. Medina, A. Mehari, Fabiola Mejía-Rodríguez, A. Mekonnen, Y. Melaku, Z. Memish, W. Mendoza, Gert B. M. Mensink, A. Meretoja, T. Meretoja, Y. Mesfin, F. Mhimbira, Anoushka I Millear, T. Miller, E. Mills, M. Mirarefin, Awoke Misganaw, C. Mock, A. Mohammadi, S. Mohammed, G. Mola, L. Monasta, J. M. Hernandez, M. Montico, L. Morawska, R. Mori, D. Mozaffarian, U. Mueller, Erin C. Mullany, J. Mumford, G. Murthy, J. Nachega, A. Naheed, V. Nangia, N. Nassiri, J. Newton, Marie Ng, Q. Nguyen, M. I. Nisar, P. M. N. Pete, O. Norheim, Rosana E Norman, B. Norrving, L. Nyakarahuka, C. Obermeyer, F. Ogbo, I. Oh, Olanrewaju Oladimeji, Pedro R Olivares, H. Olsen, B. Olusanya, J. Olusanya, John Nelson Opio, Eyal Oren, R. Orozco, Alberto Ortiz, E. Ota, Mahesh Pa, A. Pana, Eun‐Kee Park, C. Parry, M. Parsaeian, Tejas Patel, A. P. Caicedo, Snehal T. Patil, S. Patten, G. Patton, N. Pearce, David M Pereira, N. Perico, K. Pesudovs, M. Petzold, M. Phillips, F. Piel, J. Pillay, D. Plass, S. Polinder, C. Pond, C. Pope, D. Pope, S. Popova, R. Poulton, F. Pourmalek, N. Prasad, M. Qorbani, Rynaz Rabiee, A. Radfar, Anwar Rafay, V. Rahimi-Movaghar, Mahfuzar Rahman, Mohammad Hifz Ur Rahman, S. Rahman, R. Rai, Sasa Rajsic, M. Raju, U. Ram, S. Rana, K. Ranganathan, P. Rao, Christian García, A. Refaat, C. Rehm, J. Rehm, Nikolas Reinig, G. Remuzzi, S. Resnikoff, A. Ribeiro, J. Rivera, H. S. Roba, Alina Rodriguez, S. Rodríguez-Ramírez, D. Rojas-Rueda +499 moresemanticscholar +1 more sourcePARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer +21 morewiley +1 more sourceA comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
The Lancet, 2012 Stephen S. Lim, T. Vos, A. Flaxman, G. Danaei, K. Shibuya, Heather Adair-Rohani, Mohammad A. Almazroa, M. Amann, H. R. Anderson, K. Andrews, M. Aryee, C. Atkinson, L. Bacchus, A. Bahalim, K. Balakrishnan, J. Balmes, S. Barker-Collo, A. Baxter, M. Bell, J. Blore, F. Blyth, C. Bonner, G. Borges, R. Bourne, M. Boussinesq, M. Brauer, P. Brooks, N. Bruce, B. Brunekreef, C. Bryan-Hancock, C. Bucello, R. Buchbinder, F. Bull, R. Burnett, T. Byers, Bianca Calabria, J. Carapetis, Emily Carnahan, Z. Chafe, F. Charlson, Honglei Chen, J. S. Chen, A. T. Cheng, J. C. Child, A. Cohen, K. Colson, B. Cowie, Sarah C. Darby, S. Darling, A. Davis, L. Degenhardt, F. Dentener, D. Jarlais, K. Devries, M. Dherani, E. Ding, E. Dorsey, T. Driscoll, K. Edmond, Suad Eltahir Ali, Rebecca E. Engell, P. Erwin, S. Fahimi, Gail Falder, F. Farzadfar, A. Ferrari, M. Finucane, S. Flaxman, F. Fowkes, Greg Freedman, Michael K. Freeman, E. Gakidou, Santu Ghosh, E. Giovannucci, G. Gmel, Kathryn Graham, R. Grainger, B. Grant, D. Gunnell, H. Gutierrez, Wayne Hall, H. Hoek, A. Hogan, H. Hosgood, D. Hoy, Howard Hu, B. Hubbell, S. Hutchings, Sydney E. Ibeanusi, G. Jacklyn, Rashmi Jasrasaria, J. Jonas, H. Kan, J. Kanis, N. Kassebaum, N. Kawakami, Y. Khang, S. Khatibzadeh, J. Khoo, Cindy Kok, F. Laden, R. Lalloo, Q. Lan, T. Lathlean, J. Leasher, J. Leigh, Yang Li, J. Lin, S. Lipshultz, S. London, R. Lozano, Yuan Lu, J. Mak, R. Malekzadeh, Leslie Mallinger, W. Marcenes, L. March, Robert G. Marks, R. Martin, P. McGale, J. Mcgrath, S. Mehta, Z. Memish, G. Mensah, T. Merriman, R. Micha, C. Michaud, V. Mishra, Khayriyyah Mohd Hanafiah, A. Mokdad, L. Morawska, D. Mozaffarian, Tasha B. Murphy, M. Naghavi, B. Neal, P. Nelson, J. Nolla, Rosana E Norman, Casey Olives, S. Omer, J. Orchard, R. Osborne, B. Ostro, A. Page, K. Pandey, C. Parry, E. Passmore, Jayadeep Patra, N. Pearce, P. Pelizzari, M. Petzold, M. Phillips, D. Pope, C. Pope, J. Powles, M. Rao, H. Razavi, E. Rehfuess, J. Rehm, B. Ritz, F. Rivara, Thomas J Roberts, Carolyn Robinson, J. A. Rodriguez-Portales, I. Romieu, R. Room, Lisa C Rosenfeld, Ananya Roy, L. Rushton, J. Salomon, Uchechukwu Sampson, L. Sànchez-Riera, Ella Sanman, A. Sapkota, S. Seedat, P. Shi, K. Shield, R. Shivakoti, Gitanjali M Singh, D. Sleet, Emma Smith, Kirk R. Smith, Nicolas J. C. Stapelberg, K. Steenland, H. Stöckl, L. Stovner, K. Straif, L. Straney, G. Thurston, Jimmy H. Tran, R. Dingenen, A. Donkelaar, J. Veerman, L. Vijayakumar, Robert Weintraub, M. Weissman, Richard A. White, H. Whiteford, S. Wiersma, J. Wilkinson, H. Williams, Warwick Williams, N. Wilson, A. Woolf, P. Yip, J. Zielinski, Alan D. Lopez, C. Murray, M. Ezzati +208 moresemanticscholar +1 more source
