Results 161 to 170 of about 6,297,835 (358)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Hepatitis E virus: a foodborne pathogen of concern in China

One Health Advances
Hepatitis E, caused by hepatitis E virus (HEV), is a major global health concern with an estimated 20 million infections and 3.3 million symptomatic cases annually, resulting in approximately 44,000 deaths.
Jiahui Wang, Suzie Coughlan, Fengqin Li, Gabriel Gonzalez, Séamus Fanning, Nan Li, Yinping Dong, Tao Jiang   +7 more
doaj   +1 more source

Risk Assessment for Birth Defects in Offspring of Chinese Pregnant Women [PDF]

, 2022
Pengfei Qu, Doudou Zhao, Mingxin Yan, Danmeng Liu, Leilei Pei, Lingxia Zeng, Hong Yan, Shaonong Dang   +7 more
openalex   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Benefit‐risk assessment for sofosbuvir/velpatasvir/voxilaprevir based on patient population and hepatitis C virus genotype: U. S. Food and Drug Administration's evaluation [PDF]

, 2017
Kimberly Struble, Kirk M. Chan‐Tack, Karen Qi, Lisa K. Naeger, Debra Birnkrant   +4 more
openalex   +1 more source

Cross-infection risk assessment in dental clinic: Numerical investigation of emitted droplets during different atomization procedures

, 2023
Xiujie Li, Cheuk Ming Mak, Zhengtao Ai, Kuen Wai, Hai Ming Wong   +4 more
openalex   +2 more sources

Arsenic risk assessment. [PDF]

Environmental Health Perspectives, 1995
A H Smith, M L Biggs, C Hopenhayn-Rich, D Kalman   +3 more
openaire   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Pharmaceuticals in a Mediterranean Basin: The influence of temporal and hydrological patterns in environmental risk assessment

, 2019
Patrícia Palma, Sofia Fialho, Ana Lima, María Helena Novais, María João Costa, Nicola Montemurro, Sandra Pérez, Miren López de Alda   +7 more
openalex   +2 more sources

Characteristics and Risk Assessments of Mercury Pollution Levels at Domestic Garbage Collection Points Distributed within the Main Urban Areas of Changchun City [PDF]

, 2021
Zhaojun Wang, Yanjie Zhang, Lei Wang, Xu Li, Xuhang Zhou, Xiangyun Li, Mengping Yan, Qiuming Lu, Zhanhui Tang, Gang Zhang, Deli Wang   +10 more
openalex   +1 more source