Results 191 to 200 of about 17,469,113 (405)
Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal +16 morewiley +1 more sourceNext‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner +4 morewiley +1 more sourceGlobal, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
The Lancet, 2017 E. Gakidou, A. Afshin, A. Abajobir, K. H. Abate, C. Abbafati, K. Abbas, F. Abd-Allah, A. Abdulle, S. Abera, V. Aboyans, L. Abu-Raddad, Niveen M. E. Abu-Rmeileh, G. Abyu, I. Adedeji, O. Adetokunboh, M. Afarideh, Anurag Agrawal, S. Agrawal, A. Kiadaliri, H. Ahmadieh, M. Ahmed, Amani Nidhal Aichour, Ibtihel Aichour, Miloud Taki Eddine Aichour, R. Akinyemi, N. Akseer, Fares Alahdab, Z. Al-Aly, K. Alam, N. Alam, Tahiya Alam, D. Alasfoor, K. Alene, Komal Ali, Reza Alizadeh-Navaei, A. Alkerwi, F. Alla, P. Allebeck, R. Al-Raddadi, U. Alsharif, K. Altirkawi, N. Alvis-Guzmán, Azmeraw T. Amare, E. Amini, W. Ammar, Y. Amoako, H. Ansari, J. Antó, C. Antonio, P. Anwari, N. Arian, J. Ärnlöv, A. Artaman, K. Aryal, H. Asayesh, S. W. Asgedom, T. Atey, L. Ávila-Burgos, Euripide Avokpaho, A. Awasthi, P. Azzopardi, U. Bacha, A. Badawi, K. Balakrishnan, S. Ballew, A. Barać, Ryan Barber, S. Barker-Collo, T. Bärnighausen, S. Barquera, L. Barregard, L. Barrero, C. Batis, K. Battle, B. Baune, J. Beardsley, Neeraj Bedi, E. Beghi, M. Bell, D. Bennett, James R. Bennett, I. Benseñor, A. Berhane, D. F. Berhe, E. Bernabé, B. Betsu, M. Beuran, A. Beyene, A. Bhansali, Z. Bhutta, B. Bikbov, C. Birungi, S. Biryukov, C. Blosser, D. Boneya, I. Bou-Orm, M. Brauer, N. Breitborde, H. Brenner, T. Brugha, L. Bulto, Bl Baumgarner, Z. Butt, Lucero Cahuana-Hurtado, Rosario Cárdenas, J. Carrero, C. Castañeda-Orjuela, F. Catalá-López, Kelly M. Cercy, Hsing-Yi Chang, F. Charlson, Odgerel Chimed-Ochir, V. Chisumpa, Abdulaal Chitheer, H. Christensen, D. Christopher, M. Cirillo, A. Cohen, H. Comfort, C. Cooper, J. Coresh, Leslie Cornaby, P. Cortesi, M. Criqui, J. Crump, L. Dandona, R. Dandona, J. Neves, G. Davey, D. Davițoiu, K. Davletov, B. Courten, L. Degenhardt, Selina Deiparine, R. Dellavalle, Kebede Deribe, A. Deshpande, S. Dharmaratne, E. Ding, S. Djalalinia, H. Do, K. Dokova, D. Doku, E. Dorsey, T. Driscoll, M. Dubey, B. Duncan, Sarah Duncan, Natalie Ebert, H. Ebrahimi, Z. El-Khatib, A. Enayati, A. Endries, S. Ermakov, H. Erskine, B. Eshrati, S. Eskandarieh, A. Esteghamati, Kara Estep, E. J. Faraon, C. Farinha, Andre Faro, F. Farzadfar, K. Fay, V. Feigin, S. Fereshtehnejad, João Fernandes, A. Ferrari, T. R. Feyissa, I. Filip, F. Fischer, C. Fitzmaurice, A. Flaxman, N. Foigt, Kyle Foreman, J. Frostad, N. Fullman, Thomas Fürst, J. Furtado, M. Ganji, A. García-Basteiro, T. Gebrehiwot, J. Geleijnse, Ayele Geleto, Bikila Lencha Gemechu, H. Gesesew, P. Gething, A. Ghajar, K. Gibney, P. Gill, R. Gillum, A. Z. Giref, Melkamu Dedefo Gishu, G. Giussani, W. Godwin, P. Gona, A. Goodridge, S. Gopalani, Y. Goryakin, A. Goulart, Nicholas Graetz, H. Gugnani, Jingwen Guo, Rajeev Gupta, Tanush Gupta, Vipin Gupta, R. A. Gutiérrez, V. Hachinski, N. Hafezi-Nejad, G. B. Hailu, R. Hamadeh, S. Hamidi, M. Hammami, A. Handal, G. Hankey, H. Harb, H. A. Hareri, Mohammad Sadegh Hassanvand, Rasmus J. Havmoeller, Caitlin N Hawley, Simon Iain Hay, M. Hedayati, D. Hendrie, I. Heredia-Pi, H. Hoek, N. Horita, H. Hosgood, S. Hostiuc, D. Hoy, M. Hsairi, G. Hu, Hsiang Huang, John J Emmanuel Huang, K. Iburg, C. Ikeda, M. Inoue, C. Irvine, M. Jackson, K. Jacobsen, N. Jahanmehr, M. Jakovljevic, Alejandra Jáuregui, Mehdi Javanbakht, P. Jeemon, L. Johansson, C. Johnson, J. Jonas, M. Jürisson, Z. Kabir, R. Kadel, Amaha Kahsay, R. Kamal, A. Karch, C. Karema, A. Kasaeian, N. Kassebaum, A. Kastor, S. Katikireddi, N. Kawakami, P. Keiyoro, Sefonias Getachew Kelbore, L. Kemmer, A. Kengne, C. Kesavachandran, Y. Khader, I. Khalil, E. Khan, Y. Khang, A. Khosravi, J. Khubchandani, C. Kieling, Daniel H. Kim, J. Y. Kim, Y. Kim, R. Kimokoti, Y. Kinfu, A. Kisa, K. Kissimova-Skarbek, M. Kivimäki, L. Knibbs, A. Knudsen, J. Kopec, S. Kosen, P. Koul, A. Koyanagi, M. Kravchenko, Kristopher J. Krohn, H. Kromhout, B. K. Defo, B. K. Bicer, G. Kumar, Michael Kutz, H. Kyu, D. Lal, R. Lalloo, T. Lallukka, Q. Lan, V. Lansingh, A. Larsson, Alexander Lee, P. Lee, J. Leigh, J. Leung, M. Levi, Yichong Li, Yongmei Li, Xiaofeng Liang, Misgan Legesse Liben, S. Linn, Patrick Y. Liu, R. Lodha, G. Logroscino, Katherine J. Looker, Alan D. Lopez, S. Lorkowski, P. Lotufo, R. Lozano, R. Lunevicius, Erlyn K Macarayan, H. A. E. Razek, M. Razek, M. Majdan, R. Majdzadeh, A. Majeed, R. Malekzadeh, R. Malhotra, D. Malta, A. Mamun, Helena Manguerra, L. Mantovani, C. Mapoma, R. Martin, J. Martínez-Raga, F. R. Martins-Melo, M. Mathur, K. Matsushita, R. Matzopoulos, M. Mazidi, C. McAlinden, J. Mcgrath, S. Mehata, M. Mehndiratta, T. Meier, Y. Melaku, P. Memiah, Z. Memish, W. Mendoza, M. M. Mengesha, G. Mensah, Gert B. M. Mensink, S. T. Mereta, A. Meretoja, T. Meretoja, H. Mezgebe, R. Micha, Anoushka I Millear, T. Miller, S. Minnig, M. Mirarefin, E. Mirrakhimov, A. Misganaw, S. Mishra, K. Mohammad, Kedir Mohammed Oumer, S. Mohammed, N. Ibrahim, Murali B. V. Mohan, A. Mokdad, L. Monasta, J. M. Hernandez, M. Montico, M. Moradi-Lakeh, Paula Moraga, L. Morawska, S. Morrison, Cliff Mountjoy-Venning, U. Mueller, Erin C. Mullany, Kate Muller, G. Murthy, K. I. Musa, M. Naghavi, A. Naheed, V. Nangia, G. Natarajan, Ionut Negoi, R. Negoi, C. Nguyen, Grant Nguyen, Minh Nguyen, Q. Nguyen, T. H. Nguyen, E. Nichols, D. N. A. Ningrum, Marika Nomura, V. M. Nong, O. Norheim, B. Norrving, J. Noubiap, C. Obermeyer, F. Ogbo, Hwan-Jung Oh, Olanrewaju Oladimeji, A. Olagunju, T. Olagunju, Pedro R Olivares, H. Olsen, B. Olusanya, J. Olusanya, John Nelson Opio, Eyal Oren, Alberto Ortiz, E. Ota, M. Owolabi, Mahesh Pa, R. Pacella, A. Pana, B. Panda, S. Panda-Jonas, J. Pandian, C. Papachristou, Eun‐Kee Park, C. Parry, S. Patten, G. Patton, David M Pereira, N. Perico, K. Pesudovs, M. Petzold, M. Phillips, J. Pillay, M. Piradov, F. Pishgar, D. Plass, Martin A Pletcher, S. Polinder, S. Popova, R. Poulton, F. Pourmalek, N. Prasad, Carrie Purcell, M. Qorbani, A. Radfar, Anwar Rafay, A. Rahimi-Movaghar, V. Rahimi-Movaghar, Mahfuzar Rahman, Mohammad Hifz Ur Rahman, M. Rahman, R. Rai, Sasa Rajsic, U. Ram, S. Rawaf, C. Rehm, J. Rehm, R. Reiner, M. Reitsma, L. Reynales-Shigematsu, G. Remuzzi, A. Renzaho, S. Resnikoff, S. Rezaei, A. Ribeiro, J. Rivera, K. Roba, D. Rojas-Rueda, Yesenia Román, R. Room, G. Roshandel, Gregory A. Roth, D. Rothenbacher, Enrico Rubagotti, L. Rushton, Nafis Sadat, M. Safdarian, S. Safi, S. Safiri, R. Sahathevan, Joseph S. Salama, J. Salomon, A. Samy, J. Sanabria, M. Sánchez-Niño, Tania G. Sánchez-Pimienta, D. Santomauro, I. Santos, M. Milicevic, B. Sartorius, Maheswar Satpathy, M. Sawhney, S. Saxena, E. Schaeffner, M. Schmidt, I. Schneider, A. Schutte, D. Schwebel, F. Schwendicke, S. Seedat, S. Sepanlou, Berrin Serdar +499 moresemanticscholar +1 more sourceMonitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien +35 morewiley +1 more sourceDeveloping evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking +43 morewiley +1 more sourceLDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber +13 morewiley +1 more source
