Results 61 to 70 of about 5,872,978 (311)
Advanced Science, EarlyView.This study identifies Nupr1 as a crucial stress‐responsive orchestrator driving AD. Under severe stress, Nupr1 massively accumulates within mitochondria to sequester p53, triggering apoptosis and concurrently repressing the Gadd45b‐mediated survival program.
Xi Yang +14 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu +12 more
wiley +1 more source
Advanced Science, EarlyView.This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun +12 more
wiley +1 more source
Gender Differences in Risk Aversion and Ambiguity Aversion [PDF]
Journal of the European Economic Association, 2009 This paper demonstrates gender differences in risk aversion and ambiguity aversion. It also contributes to a growing literature relating economic preference parameters to psychological measures by asking whether variations in preference parameters among persons, and in particular across genders, can be accounted for by differences in personality traits
Lex Borghans +3 more
openaire +6 more sources
Blocking Honeybee Preference for Neonicotinoids by Interfering With Dopamine Signaling
Advanced Science, EarlyView.Honeybees (Apis mellifera) paradoxically prefer nectar containing the harmful neonicotinoid thiamethoxam. This preference is associated with transient brain dopamine elevation during proboscis extension reflex (PER) responses and active feeding, and is reduced by the dopamine receptor antagonist fluphenazine.
Jing Li +5 more
wiley +1 more source
Health Shocks and Risk Aversion [PDF]
SSRN Electronic Journal, 2015 We empirically assess whether a health shock influences individual risk aversion. We use grip strength data to obtain an objective health shock indicator. In order to account for the non-random nature of our data regression-adjusted matching is employed. Risk preferences are traditionally assumed to be constant.
Decker, Simon, Schmitz, Hendrik
openaire +5 more sources
How Video‐Based Information Affects Farmers' Willingness to Pay for Drone Services
Applied Economic Perspectives and Policy, EarlyView.ABSTRACT Professional service for digital technology like agricultural drones lowers transaction costs and scope thresholds for smallholders. Meanwhile, perceptual adoption barriers remain underexplored. We conduct a two‐stage choice experiment with a randomized video‐based information treatment among 384 Chinese crop farmers to measure its effect on ...
Hua Zhang +4 more
wiley +1 more source
Foundations and Trends® in Microeconomics, 2006 The purpose of the survey is to summarize, discuss, and interpret published research concerning the risk aversion of decision makers who maximize expected utility. In doing this, two points are emphasized. First, any measure of risk aversion is specific to the particular outcome variable over which the measure is defined or estimated, and second when ...
Donald J. Meyer, Jack Meyer
openaire +2 more sources
Applied Economic Perspectives and Policy, EarlyView.ABSTRACT Growing demand for healthier beverages is driving innovation in the wine sector, with dealcoholized wine emerging as a promising alternative. However, little is known about the contextual conditions under which consumers would choose dealcoholized wine, particularly in countries with strong wine traditions. To fill this gap, this work examines
Giovanna Piracci +4 more
wiley +1 more source
RISK AVERSION BEHAVIOR. RELATIONSHIPS BETWEEN RISK AVERSION, PRUDENCE AND CAUTIOUSNESS [PDF]
This paper defines decreasing absolute risk aversion in purely behavioral termswithout any assumption of differentiability and shows that a strictly increasing and riskaverse utility function with decreasing absolute risk aversion is necessarily ...
Botoc Claudiu, Pirtea Marilen
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